Efficacy of moxidectin oral gel against Onchocerca cervicalis microfilariae

C. M. Monahan, M. R. Chapman, D. D. French, T. R. Klei

Research output: Contribution to journalArticlepeer-review


During a series of dose-titration experiments designed to evaluate the efficacy of moxidectin oral gel against equine gastrointestinal parasites, infection with Onchocerca cervicalis was diagnosed in 25 of 82 ponies prior to treatment. Microfilariae were identified in full-thickness skin biopsies taken from the ventral midline. Treatment with moxidectin in single doses of 300, 400, or 500 μg/kg of body weight was 100% effective in eliminating microfilariae from 20 skin biopsies taken 14 days posttreatment, whereas 5 microfilaria-positive ponies in 2 control groups remained positive following placebo treatment. No adverse reaction was seen in any pony following treatment with moxidectin or the vehicle control.

Original languageEnglish (US)
Pages (from-to)117-118
Number of pages2
JournalJournal of Parasitology
Issue number1
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Ecology, Evolution, Behavior and Systematics


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