TY - JOUR
T1 - Efficacy of chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in Honduras
AU - Torres, Rosa Elena Mejia
AU - Banegas, Engels Ilich
AU - Mendoza, Meisy
AU - Diaz, Cesar
AU - Bucheli, Sandra Tamara Mancero
AU - Fontecha, Gustavo A.
AU - Alam, Md Tauqeer
AU - Goldman, Ira
AU - Udhayakumar, Venkatachalam
AU - Zambrano, Jose Orlinder Nicolas
PY - 2013/5
Y1 - 2013/5
N2 - Chloroquine (CQ) is officially used for the primary treatment of Plasmodium falciparum malaria in Honduras. In this study, the therapeutic efficacy of CQ for the treatment of uncomplicated P. falciparum malaria in the municipality of Puerto Lempira, Gracias a Dios, Honduras was evaluated using the Pan American Health Organization - World Health Organization protocol with a follow-up of 28 days. Sixty-eight patients from 6 months to 60 years of age microscopically diagnosed with uncomplicated P. falciparum malaria were included in the final analysis. All patients who were treated with CQ (25 mg/kg over 3 days) cleared parasitemia by day 3 and acquired no new P. falciparum infection within 28 days of follow-up. All the parasite samples sequenced for CQ resistance mutations (pfcrt) showed only the CQ-sensitive genotype (CVMNK). This finding shows that CQ remains highly efficacious for the treatment of uncomplicated P. falciparum malaria in Gracias a Dios, Honduras.
AB - Chloroquine (CQ) is officially used for the primary treatment of Plasmodium falciparum malaria in Honduras. In this study, the therapeutic efficacy of CQ for the treatment of uncomplicated P. falciparum malaria in the municipality of Puerto Lempira, Gracias a Dios, Honduras was evaluated using the Pan American Health Organization - World Health Organization protocol with a follow-up of 28 days. Sixty-eight patients from 6 months to 60 years of age microscopically diagnosed with uncomplicated P. falciparum malaria were included in the final analysis. All patients who were treated with CQ (25 mg/kg over 3 days) cleared parasitemia by day 3 and acquired no new P. falciparum infection within 28 days of follow-up. All the parasite samples sequenced for CQ resistance mutations (pfcrt) showed only the CQ-sensitive genotype (CVMNK). This finding shows that CQ remains highly efficacious for the treatment of uncomplicated P. falciparum malaria in Gracias a Dios, Honduras.
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U2 - 10.4269/ajtmh.12-0671
DO - 10.4269/ajtmh.12-0671
M3 - Article
C2 - 23458957
AN - SCOPUS:84877122037
SN - 0002-9637
VL - 88
SP - 850
EP - 854
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -