Efficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations

Peter J. Fitschen, Gabriel J. Wilson, Jacob M. Wilson, Kenneth R. Wilund

Research output: Contribution to journalReview article

Abstract

Muscle loss is common during aging and chronic diseases, such as cancer and acquired immunodeficiency syndrome. Moreover, muscle loss has been correlated with decreased physical function, quality of life, and mortality in these populations. Therefore, interventions to counteract muscle loss in the elderly and clinical populations are needed. Recently, the efficacy of the leucine metabolite, β-hydroxy-β-methylbutyrate (HMB), to maintain muscle mass has been investigated in these populations. Many studies have found increases in lean mass and strength in the elderly and clinical populations when using HMB; however, not all studies have found beneficial effects of HMB supplementation. The present review summarizes published human studies investigating the efficacy of HMB supplementation in the elderly and clinical populations. In addition, the mechanisms by which HMB may exert its effects are summarized and future research directions are suggested.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalNutrition
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2013

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Muscles
Population
Leucine
Acquired Immunodeficiency Syndrome
Chronic Disease
Quality of Life
Mortality
Neoplasms
Direction compound

Keywords

  • Chronic disease
  • Exercise
  • Lean mass
  • Muscle
  • Wasting
  • β-Hydroxy-β-methylbutyrate B

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Efficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations. / Fitschen, Peter J.; Wilson, Gabriel J.; Wilson, Jacob M.; Wilund, Kenneth R.

In: Nutrition, Vol. 29, No. 1, 01.01.2013, p. 29-36.

Research output: Contribution to journalReview article

Fitschen, Peter J. ; Wilson, Gabriel J. ; Wilson, Jacob M. ; Wilund, Kenneth R. / Efficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations. In: Nutrition. 2013 ; Vol. 29, No. 1. pp. 29-36.
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