Effects of the herbicide Roundup on the epididymal region of drakes Anas platyrhynchos

André G. Oliveira, Luiz F. Telles, Rex A. Hess, Germán A.B. Mahecha, Cleida A. Oliveira

Research output: Contribution to journalArticlepeer-review

Abstract

Exposure to the Roundup has been shown to affect StAR protein and aromatase expression and activity, pointing out that this herbicide may cause adverse effects in animal reproduction by affecting androgen and estrogen synthesis. We tested this hypothesis by investigating the in vivo effects of the Roundup on the testis and epididymal region of drake Anas platyrhynchos. The exposure to the herbicide resulted in alterations in the structure of the testis and epididymal region as well as in the serum levels of testosterone and estradiol, with changes in the expression of androgen receptors restricted to the testis. The harmful effects were more conspicuous in the proximal efferent ductules and epididymal ducts, suggesting higher sensitivity of these segments among the male genital organs. The effects were mostly dose dependent, indicating that this herbicide may cause disorder in the morphophysiology of the male genital system of animals.

Original languageEnglish (US)
Pages (from-to)182-191
Number of pages10
JournalReproductive Toxicology
Volume23
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Androgen receptor
  • Efferent ductules
  • Endocrine disruption
  • Epididymal region
  • Glyphosate
  • Roundup
  • drake

ASJC Scopus subject areas

  • Toxicology

Fingerprint

Dive into the research topics of 'Effects of the herbicide Roundup on the epididymal region of drakes Anas platyrhynchos'. Together they form a unique fingerprint.

Cite this