Effects of short-chain fatty acid-supplemented total parenteral nutrition on intestinal pro-inflammatory cytokine abundance

L. A. Milo, K. A. Reardon, Kelly A. Tappenden

Research output: Contribution to journalArticle

Abstract

We examined the effect of short-chain fatty acid-supplemented total parenteral nutrition on proinflammatory cytokine levels in piglets. Piglets (N = 22) received either standard total parenteral nutrition or total parenteral nutrition supplemented with short-chain fatty acids. After seven days of continuous nutrient infusion, proinflammatory cytokine (TNF-α, IL-1β, IL-6) abundance in plasma, jejunal, and ileal samples and small intestinal myeloperoxidase was determined using western blotting. No differences were seen in TNF-α small intestinal abundance. IL-1β was higher in the small intestine of the short-chain fatty acid group (P < 0.05). IL-6 was higher in intestinal samples of the short-chain fatty acid group (P = 0.05), with the ileum having a greater abundance of IL-6 than the jejunum (P < 0.005). No differences in proinflammatory cytokine abundance in the plasma or tissue myeloperoxidase were seen. These results indicate short-chain fatty acids beneficially increase small intestinal abundance of IL-1β and IL-6 during total parenteral nutrition administration, while not affection systemic production of these cytokines or intestinal inflammation.

Original languageEnglish (US)
Pages (from-to)2049-2055
Number of pages7
JournalDigestive Diseases and Sciences
Volume47
Issue number9
DOIs
StatePublished - Sep 1 2002

Keywords

  • Myeloperoxidase
  • Proinflammatory cytokines
  • Short-chain fatty acids
  • Small intestine
  • Total parenteral nutrition

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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