Effects of personalized depression prevention on anxiety through 18-month follow-up: A randomized controlled trial

Jason D. Jones, Benjamin L. Hankin, Robert Gallop, Dustin Haraden, Marissa D. Sbrilli, Judy Garber, Jami F. Young

Research output: Contribution to journalArticlepeer-review


Depression and anxiety frequently co-occur and share several risk factors. There is some evidence for transdiagnostic effects of prevention programs on depression and anxiety. In the Personalized Depression Prevention (PDP) study, youth (n = 98, Mage = 13.94 years, SD = 1.67) were classified as high or low on cognitive and interpersonal risk factors and randomized to either a cognitive-behavioral or an interpersonal prevention program. Some participants received a match between risk and prevention, others received a mismatch. Our initial work found evidence for the benefits of personalization on depression outcomes. In this paper, we focus on secondary anxiety outcomes through 18-months post-intervention. We found evidence for the benefits of personalized prevention on anxiety symptoms during the 18-month follow-up period, but not during the intervention. From post-intervention to 18-month follow-up matched youth showed a decrease in anxiety symptoms whereas mismatched youth showed a significant increase in symptoms (d = 0.87, p = .001). The rates of anxiety disorders were equivalent across the groups (p = 1.00). Given the comorbidity of depression and anxiety, interventions that have effects on both may be an efficient and cost-effective approach to reducing the burden associated with these conditions. A risk-informed personalization approach to prevention may be one way to enhance the transdiagnostic effects of depression prevention.

Original languageEnglish (US)
Article number104156
JournalBehaviour Research and Therapy
StatePublished - Sep 2022


  • Adolescents
  • Anxiety
  • Depression
  • Personalization
  • Prevention
  • Transdiagnostic

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Psychiatry and Mental health
  • Clinical Psychology


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