Passive immune protection in ruminants is achieved by the ingestion and absorption of adequate amounts of colostral immunoglobulins. The objective of this study was to determine the effect of omeprazole and pantoprazole administration on gamma globulin (IgG) absorption in the newborn calves fed with colostrum and fresh milk. A total of 21 newborn Holstein-Friesian calves were included in this study. The calves were randomly assigned into seven groups including three control and four treatment groups. Each group consisted of three calves. The calves in the control groups designated as CTRL1-3 were fed 2 L of fresh milk by esophageal tube immediately after birth and every 12 h until 24 h (CTRL1) or until 48 h (CTRL2). Then, they received 2 L of pooled colostrum every 12 h until 72 h after birth. The calves in CTRL3 were fed 2 L of pooled colostrum by esophageal tube immediately after birth and every 12 h until 72 h after birth. The calves in the treatment groups were essentially fed the same as control groups. In addition, they received either omeprazole orally or pantoprazole via intravenous administration. Blood samples were obtained by jugular venipuncture at 0, 6, 12, 24, 36, 48, 60, 72, and 84 h after birth. Serum IgG concentration was determined by using a commercially available enzyme-linked immunosorbent assay kit. No statistically significant differences were found in the serum IgG concentrations at different time points between the calves that received either omeprazole or pantoprazole and the control groups. In conclusion, the results of this study showed that increasing pH of the abomasum with proton pump inhibition drugs such as omeprazole and pantoprazole did not markedly influence the efficiency of IgG absorption in newborn calves.
ASJC Scopus subject areas
- Pathology and Forensic Medicine