TY - JOUR
T1 - Effects of maternal exposure to chlorinated diphenyl ethers on thyroid hormone concentrations in maternal and juvenile rats
AU - Rosiak, Kimberly L.
AU - Seo, Byung Woun
AU - Chu, Ih
AU - Francis, B. Magnus
N1 - Funding Information:
This work was supported by Health Canada Project # 4067, by the Research
PY - 1997
Y1 - 1997
N2 - Polychlorinated diphenyl ethers (PCDEs) are industrial byproducts and widespread environmental contaminants. Their structural similarity to PCBs suggests that they may exhibit subtle effects on both adult and juvenile mammals. We examined the effects of 3 PCDEs (2,21,4,5,61- pentachlorodiphenyl ether, 21,3,4,61-tetrachlorodiphenyl ether, and 2,21,4,41,5,51-hexachlorodiphenyl ether) on maternal rat thyroid levels shortly after exposure, and on the thyroid levels of 16 day old juvenile rats that had been prenatally exposed. Both 2,21,4,5,61-pentachlorodiphenyl ether and 21,3,4,61-tetrachlorodiphenyl ether depressed thyroxine (T4) levels in the maternal females as well as in both sexes of juvenile rats. 2,21,4,41,5,51-hexachlorodiphenyl ether did not alter T4 levels in the pregnant females, but depressed juvenile T4 levels. None of the congeners studied significantly altered T3 levels. Effects on thyroid hormones did not correlate with the congeners' induction of cytochrome P450.
AB - Polychlorinated diphenyl ethers (PCDEs) are industrial byproducts and widespread environmental contaminants. Their structural similarity to PCBs suggests that they may exhibit subtle effects on both adult and juvenile mammals. We examined the effects of 3 PCDEs (2,21,4,5,61- pentachlorodiphenyl ether, 21,3,4,61-tetrachlorodiphenyl ether, and 2,21,4,41,5,51-hexachlorodiphenyl ether) on maternal rat thyroid levels shortly after exposure, and on the thyroid levels of 16 day old juvenile rats that had been prenatally exposed. Both 2,21,4,5,61-pentachlorodiphenyl ether and 21,3,4,61-tetrachlorodiphenyl ether depressed thyroxine (T4) levels in the maternal females as well as in both sexes of juvenile rats. 2,21,4,41,5,51-hexachlorodiphenyl ether did not alter T4 levels in the pregnant females, but depressed juvenile T4 levels. None of the congeners studied significantly altered T3 levels. Effects on thyroid hormones did not correlate with the congeners' induction of cytochrome P450.
KW - Chlorinated diphenyl ethers
KW - rats
KW - thyroid hormones
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U2 - 10.1080/03601239709373093
DO - 10.1080/03601239709373093
M3 - Article
C2 - 9177011
AN - SCOPUS:0030898799
SN - 0360-1234
VL - 32
SP - 377
EP - 393
JO - Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes
JF - Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes
IS - 3
ER -