TY - JOUR
T1 - Effects of long-term overfeeding on plasma lipoprotein levels in identical twins
AU - Terán-García, Margarita
AU - Després, Jean Pierre
AU - Couillard, Charles
AU - Tremblay, Angelo
AU - Bouchard, Claude
N1 - Funding Information:
We are indebted to Jacques Bouillon, Suzie Hamel, Brigitte Zément, Maryse Lebrun, Martine Marcotte, Monique Chagnon, Josée Lapointe, Henri Bessette, Gilles Bouchard, and Serge Carbonneau for contributions to this study. Special thanks to Guy Fournier and Dr. Germain Thériault for their role in the management of the study. Thanks also to Claude Leblanc for statistical support. Charles Couillard is a research fellow of the Fonds de la recherche en santé du Québec (FRSQ). This research was supported in part by National Institute of Diabetes and Digestive and Kidney Diseases Grant DK-34624. C. Bouchard is supported in part by the George A. Bray Chair in Nutrition. This work was supported by a grant from the National Institutes of Health DK34624.
PY - 2004/4
Y1 - 2004/4
N2 - Twelve pairs of male monozygotic (MZ) twins (mean age±S.D.: 21±2 years) were subjected to an overfeeding protocol of 4.2MJ (1000kcal) above their pre-established individual daily energy needs, 6 days a week, over a period of 100 days. Body weight increased significantly (gain of 8.1kg, P<0.001), as did fat mass (5.4kg, P<0.001) after overfeeding. Plasma triacylglycerol (TG) levels significantly increased (P<0.05) without change in plasma cholesterol (CHOL). Plasma very-low-density-lipoprotein (VLDL)-TG, VLDL-Apoprotein (Apo) B, low-density-lipoprotein cholesterol (LDL-C) and LDL-Apo B (P≤0.05) rose, whereas high-density-lipoprotein cholesterol (HDL-C) levels fell (P<0.05) raising the CHOL/HDL-C ratio (20%) (P<0.001). Considerable individual differences occurred in plasma lipoprotein responses to overfeeding. However, these changes were not random; significant within-pair resemblance registered for the response of plasma CHOL, TG, VLDL-TG, VLDL-C, LDL-TG, HDL-C, HDL-Apo A-I, HDL2-C, HDL3-C to overfeeding (0.48≤ri≤0.85). Furthermore, a high within-pair resemblance was found for changes in ratios of CHOL/HDL-C (ri=0.86, P<0.0001) and HDL2-C/HDL3-C (ri=0.69, P<0.01). These results strongly suggest that the response of plasma lipoproteins to chronic energy surplus has a significant genetic component as does the detrimental effect of chronic caloric affluence on CHD risk.
AB - Twelve pairs of male monozygotic (MZ) twins (mean age±S.D.: 21±2 years) were subjected to an overfeeding protocol of 4.2MJ (1000kcal) above their pre-established individual daily energy needs, 6 days a week, over a period of 100 days. Body weight increased significantly (gain of 8.1kg, P<0.001), as did fat mass (5.4kg, P<0.001) after overfeeding. Plasma triacylglycerol (TG) levels significantly increased (P<0.05) without change in plasma cholesterol (CHOL). Plasma very-low-density-lipoprotein (VLDL)-TG, VLDL-Apoprotein (Apo) B, low-density-lipoprotein cholesterol (LDL-C) and LDL-Apo B (P≤0.05) rose, whereas high-density-lipoprotein cholesterol (HDL-C) levels fell (P<0.05) raising the CHOL/HDL-C ratio (20%) (P<0.001). Considerable individual differences occurred in plasma lipoprotein responses to overfeeding. However, these changes were not random; significant within-pair resemblance registered for the response of plasma CHOL, TG, VLDL-TG, VLDL-C, LDL-TG, HDL-C, HDL-Apo A-I, HDL2-C, HDL3-C to overfeeding (0.48≤ri≤0.85). Furthermore, a high within-pair resemblance was found for changes in ratios of CHOL/HDL-C (ri=0.86, P<0.0001) and HDL2-C/HDL3-C (ri=0.69, P<0.01). These results strongly suggest that the response of plasma lipoproteins to chronic energy surplus has a significant genetic component as does the detrimental effect of chronic caloric affluence on CHD risk.
KW - Genetic susceptibility
KW - Lipoprotein
KW - Obesity
KW - Overfeeding
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U2 - 10.1016/j.atherosclerosis.2003.12.016
DO - 10.1016/j.atherosclerosis.2003.12.016
M3 - Article
C2 - 15064102
AN - SCOPUS:1842666897
SN - 0021-9150
VL - 173
SP - 277
EP - 283
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -