TY - JOUR
T1 - Effects of freeze-thaw and micro-computed tomography irradiation on structure-property relations of porcine trabecular bone
AU - Lee, Woowon
AU - Jasiuk, Iwona
N1 - Funding Information:
We would like to thank the staff at the Imaging Technology Group at the Beckman Institute, Leilei Yin and Mark Bee, for their help in operating the micro-CT equipment, and Travis Ross and Scott Robinson for their assistance in micro-CT imaging. We would also like to thank Professor Ryan Roeder from the University of Notre Dame for providing standards and his guidance on measuring bone mineral density. This research was supported by the National Science Foundation ( CMMI 09-27909 ARRA, Dr. Ken Chong). We have no conflict of interest to report.
PY - 2014/4/11
Y1 - 2014/4/11
N2 - We study the effects of freeze-thaw and irradiation on structure-property relations of trabecular bone. We measure the porosity, apparent density, mineral content, trabecular orientation, trabecular thickness, fractal dimension, surface area, and connectivity of trabecular bone using micro-computed tomography (micro-CT) and relate them to Young[U+05F3]s modulus and ultimate strength measured by uniaxial compression testing. The analysis is done on six-month porcine trabecular bone from femoral heads. The effects of freeze-thaw are studied by using bones from three different groups: fresh bone and bones frozen for one and five years. We find that the porosity and apparent density have most dominant influence on the elastic modulus and strength of fresh bone. Also, five years of freezing lowers both Young[U+05F3]s modulus and ultimate strength of trabecular bone. Additionally, the effects of radiation are investigated by comparing Young[U+05F3]s modulus before and after micro-CT exposure. We find that the micro-CT irradiation has a negligible effect on the Young[U+05F3]s modulus of trabecular bone. These findings provide insights on the effects of tissue preservation and imaging on properties of trabecular bone.
AB - We study the effects of freeze-thaw and irradiation on structure-property relations of trabecular bone. We measure the porosity, apparent density, mineral content, trabecular orientation, trabecular thickness, fractal dimension, surface area, and connectivity of trabecular bone using micro-computed tomography (micro-CT) and relate them to Young[U+05F3]s modulus and ultimate strength measured by uniaxial compression testing. The analysis is done on six-month porcine trabecular bone from femoral heads. The effects of freeze-thaw are studied by using bones from three different groups: fresh bone and bones frozen for one and five years. We find that the porosity and apparent density have most dominant influence on the elastic modulus and strength of fresh bone. Also, five years of freezing lowers both Young[U+05F3]s modulus and ultimate strength of trabecular bone. Additionally, the effects of radiation are investigated by comparing Young[U+05F3]s modulus before and after micro-CT exposure. We find that the micro-CT irradiation has a negligible effect on the Young[U+05F3]s modulus of trabecular bone. These findings provide insights on the effects of tissue preservation and imaging on properties of trabecular bone.
KW - Compression test
KW - Freeze-thaw
KW - Micro-CT
KW - Structure-property relations
KW - Trabecular bone
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U2 - 10.1016/j.jbiomech.2014.02.022
DO - 10.1016/j.jbiomech.2014.02.022
M3 - Article
C2 - 24612985
AN - SCOPUS:84896473739
SN - 0021-9290
VL - 47
SP - 1495
EP - 1498
JO - Journal of Biomechanics
JF - Journal of Biomechanics
IS - 6
ER -