Effects of dietary soybean meal concentration on growth and immune response of pigs infected with porcine reproductive and respiratory syndrome virus

S. J. Rochell, L. S. Alexander, G. C. Rocha, W. G. Van Alstine, R. D. Boyd, J. E. Pettigrew, Ryan Neil Dilger

Research output: Contribution to journalArticle

Abstract

An experiment was conducted to determine the effects of dietary soybean meal (SBM) concentration on the growth performance and immune response of pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). Four experimental treatments included a 2 × 2 factorial arrangement of 2 dietary SBM concentrations, 17.5% (LSBM) or 29% (HSBM), and 2 levels of PRRSV infection, uninfected sham or PRRSV infected. Sixtyfour weanling pigs of split sex (21 d of age, 7.14 ± 0.54 kg) were individually housed in disease containment chambers. Pigs were provided a common diet for 1 wk postweaning before being equalized for BW and sex and allotted to 4 treatment groups with 16 replicate pigs per group. Pigs were fed experimental diets for 1 wk before receiving either a sham inoculation (sterile PBS) or a 1 × 105 50% tissue culture infective dose of PRRSV at 35 d of age (0 d postinoculation, DPI). Pig BW and feed intake were recorded weekly, and rectal temperatures were measured daily beginning on 0 DPI. Blood was collected on 0, 3, 7, and 14 DPI for determination of serum PRRSV load, differential complete blood cell counts, and haptoglobin and cytokine concentrations. Infection with PRRSV increased (P < 0.01) rectal temperatures of pigs throughout the infection period, with no influence of dietary SBM concentration. Pigs in the PRRSVinfected group had lower (P < 0.01) ADFI and G:F from 0 to 14 DPI compared with uninfected pigs. In the PRRSV-infected group, pigs fed HSBM tended to have improved ADG (P = 0.06) compared with pigs fed LSBM, whereas there was no influence of SBM concentration on growth of pigs in the uninfected group. At 14 DPI, PRRSV-infected pigs fed HSBM had a lower serum PRRSV load (P < 0.05), a higher (P = 0.02) hematocrit value, and a tendency for greater hemoglobin concentration (P = 0.09) compared with pigs fed LSBM. Serum haptoglobin and tumor necrosis factor-α concentrations of PRRSV-infected pigs were lower (P < 0.05) in pigs fed HSBM at 3 and 14 DPI, respectively, than in pigs fed LSBM. Overall, increasing the dietary SBM concentration modulated the immune response and tended to improve the growth of nursery pigs during a PRRSV infection.

Original languageEnglish (US)
Pages (from-to)2987-2997
Number of pages11
JournalJournal of animal science
Volume93
Issue number6
DOIs
StatePublished - Jun 2015

Fingerprint

Porcine respiratory and reproductive syndrome virus
Porcine reproductive and respiratory syndrome virus
Soybeans
soybean meal
Meals
Swine
immune response
swine
Growth
blood serum
Haptoglobins
Blood Cell Count
haptoglobins
Virus Diseases
viral load
infection
Serum
Diet
blood cell counts

Keywords

  • Growth
  • Immune response
  • Pig
  • Porcine reproductive and respiratory syndrome virus
  • Soybean meal

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

Cite this

Effects of dietary soybean meal concentration on growth and immune response of pigs infected with porcine reproductive and respiratory syndrome virus. / Rochell, S. J.; Alexander, L. S.; Rocha, G. C.; Van Alstine, W. G.; Boyd, R. D.; Pettigrew, J. E.; Dilger, Ryan Neil.

In: Journal of animal science, Vol. 93, No. 6, 06.2015, p. 2987-2997.

Research output: Contribution to journalArticle

Rochell, S. J. ; Alexander, L. S. ; Rocha, G. C. ; Van Alstine, W. G. ; Boyd, R. D. ; Pettigrew, J. E. ; Dilger, Ryan Neil. / Effects of dietary soybean meal concentration on growth and immune response of pigs infected with porcine reproductive and respiratory syndrome virus. In: Journal of animal science. 2015 ; Vol. 93, No. 6. pp. 2987-2997.
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