Abstract
An experiment was conducted to determine the effects of dietary soybean meal (SBM) concentration on the growth performance and immune response of pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). Four experimental treatments included a 2 × 2 factorial arrangement of 2 dietary SBM concentrations, 17.5% (LSBM) or 29% (HSBM), and 2 levels of PRRSV infection, uninfected sham or PRRSV infected. Sixtyfour weanling pigs of split sex (21 d of age, 7.14 ± 0.54 kg) were individually housed in disease containment chambers. Pigs were provided a common diet for 1 wk postweaning before being equalized for BW and sex and allotted to 4 treatment groups with 16 replicate pigs per group. Pigs were fed experimental diets for 1 wk before receiving either a sham inoculation (sterile PBS) or a 1 × 105 50% tissue culture infective dose of PRRSV at 35 d of age (0 d postinoculation, DPI). Pig BW and feed intake were recorded weekly, and rectal temperatures were measured daily beginning on 0 DPI. Blood was collected on 0, 3, 7, and 14 DPI for determination of serum PRRSV load, differential complete blood cell counts, and haptoglobin and cytokine concentrations. Infection with PRRSV increased (P < 0.01) rectal temperatures of pigs throughout the infection period, with no influence of dietary SBM concentration. Pigs in the PRRSVinfected group had lower (P < 0.01) ADFI and G:F from 0 to 14 DPI compared with uninfected pigs. In the PRRSV-infected group, pigs fed HSBM tended to have improved ADG (P = 0.06) compared with pigs fed LSBM, whereas there was no influence of SBM concentration on growth of pigs in the uninfected group. At 14 DPI, PRRSV-infected pigs fed HSBM had a lower serum PRRSV load (P < 0.05), a higher (P = 0.02) hematocrit value, and a tendency for greater hemoglobin concentration (P = 0.09) compared with pigs fed LSBM. Serum haptoglobin and tumor necrosis factor-α concentrations of PRRSV-infected pigs were lower (P < 0.05) in pigs fed HSBM at 3 and 14 DPI, respectively, than in pigs fed LSBM. Overall, increasing the dietary SBM concentration modulated the immune response and tended to improve the growth of nursery pigs during a PRRSV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2987-2997 |
| Number of pages | 11 |
| Journal | Journal of animal science |
| Volume | 93 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2015 |
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Keywords
- Growth
- Immune response
- Pig
- Porcine reproductive and respiratory syndrome virus
- Soybean meal
ASJC Scopus subject areas
- Food Science
- Animal Science and Zoology
- Genetics
Cite this
Effects of dietary soybean meal concentration on growth and immune response of pigs infected with porcine reproductive and respiratory syndrome virus. / Rochell, S. J.; Alexander, L. S.; Rocha, G. C.; Van Alstine, W. G.; Boyd, R. D.; Pettigrew, J. E.; Dilger, Ryan Neil.
In: Journal of animal science, Vol. 93, No. 6, 06.2015, p. 2987-2997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of dietary soybean meal concentration on growth and immune response of pigs infected with porcine reproductive and respiratory syndrome virus
AU - Rochell, S. J.
AU - Alexander, L. S.
AU - Rocha, G. C.
AU - Van Alstine, W. G.
AU - Boyd, R. D.
AU - Pettigrew, J. E.
AU - Dilger, Ryan Neil
PY - 2015/6
Y1 - 2015/6
N2 - An experiment was conducted to determine the effects of dietary soybean meal (SBM) concentration on the growth performance and immune response of pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). Four experimental treatments included a 2 × 2 factorial arrangement of 2 dietary SBM concentrations, 17.5% (LSBM) or 29% (HSBM), and 2 levels of PRRSV infection, uninfected sham or PRRSV infected. Sixtyfour weanling pigs of split sex (21 d of age, 7.14 ± 0.54 kg) were individually housed in disease containment chambers. Pigs were provided a common diet for 1 wk postweaning before being equalized for BW and sex and allotted to 4 treatment groups with 16 replicate pigs per group. Pigs were fed experimental diets for 1 wk before receiving either a sham inoculation (sterile PBS) or a 1 × 105 50% tissue culture infective dose of PRRSV at 35 d of age (0 d postinoculation, DPI). Pig BW and feed intake were recorded weekly, and rectal temperatures were measured daily beginning on 0 DPI. Blood was collected on 0, 3, 7, and 14 DPI for determination of serum PRRSV load, differential complete blood cell counts, and haptoglobin and cytokine concentrations. Infection with PRRSV increased (P < 0.01) rectal temperatures of pigs throughout the infection period, with no influence of dietary SBM concentration. Pigs in the PRRSVinfected group had lower (P < 0.01) ADFI and G:F from 0 to 14 DPI compared with uninfected pigs. In the PRRSV-infected group, pigs fed HSBM tended to have improved ADG (P = 0.06) compared with pigs fed LSBM, whereas there was no influence of SBM concentration on growth of pigs in the uninfected group. At 14 DPI, PRRSV-infected pigs fed HSBM had a lower serum PRRSV load (P < 0.05), a higher (P = 0.02) hematocrit value, and a tendency for greater hemoglobin concentration (P = 0.09) compared with pigs fed LSBM. Serum haptoglobin and tumor necrosis factor-α concentrations of PRRSV-infected pigs were lower (P < 0.05) in pigs fed HSBM at 3 and 14 DPI, respectively, than in pigs fed LSBM. Overall, increasing the dietary SBM concentration modulated the immune response and tended to improve the growth of nursery pigs during a PRRSV infection.
AB - An experiment was conducted to determine the effects of dietary soybean meal (SBM) concentration on the growth performance and immune response of pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). Four experimental treatments included a 2 × 2 factorial arrangement of 2 dietary SBM concentrations, 17.5% (LSBM) or 29% (HSBM), and 2 levels of PRRSV infection, uninfected sham or PRRSV infected. Sixtyfour weanling pigs of split sex (21 d of age, 7.14 ± 0.54 kg) were individually housed in disease containment chambers. Pigs were provided a common diet for 1 wk postweaning before being equalized for BW and sex and allotted to 4 treatment groups with 16 replicate pigs per group. Pigs were fed experimental diets for 1 wk before receiving either a sham inoculation (sterile PBS) or a 1 × 105 50% tissue culture infective dose of PRRSV at 35 d of age (0 d postinoculation, DPI). Pig BW and feed intake were recorded weekly, and rectal temperatures were measured daily beginning on 0 DPI. Blood was collected on 0, 3, 7, and 14 DPI for determination of serum PRRSV load, differential complete blood cell counts, and haptoglobin and cytokine concentrations. Infection with PRRSV increased (P < 0.01) rectal temperatures of pigs throughout the infection period, with no influence of dietary SBM concentration. Pigs in the PRRSVinfected group had lower (P < 0.01) ADFI and G:F from 0 to 14 DPI compared with uninfected pigs. In the PRRSV-infected group, pigs fed HSBM tended to have improved ADG (P = 0.06) compared with pigs fed LSBM, whereas there was no influence of SBM concentration on growth of pigs in the uninfected group. At 14 DPI, PRRSV-infected pigs fed HSBM had a lower serum PRRSV load (P < 0.05), a higher (P = 0.02) hematocrit value, and a tendency for greater hemoglobin concentration (P = 0.09) compared with pigs fed LSBM. Serum haptoglobin and tumor necrosis factor-α concentrations of PRRSV-infected pigs were lower (P < 0.05) in pigs fed HSBM at 3 and 14 DPI, respectively, than in pigs fed LSBM. Overall, increasing the dietary SBM concentration modulated the immune response and tended to improve the growth of nursery pigs during a PRRSV infection.
KW - Growth
KW - Immune response
KW - Pig
KW - Porcine reproductive and respiratory syndrome virus
KW - Soybean meal
UR - http://www.scopus.com/inward/record.url?scp=84971440571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971440571&partnerID=8YFLogxK
U2 - 10.2527/jas.2014-8462
DO - 10.2527/jas.2014-8462
M3 - Article
C2 - 26115285
AN - SCOPUS:84971440571
VL - 93
SP - 2987
EP - 2997
JO - Journal of Animal Science
JF - Journal of Animal Science
SN - 0021-8812
IS - 6
ER -