TY - JOUR
T1 - Effects of dietary leucine and tryptophan supplementations on serotonin metabolism and growth performance of growing pigs
AU - Kwon, W. B.
AU - Touchette, K. J.
AU - Simongiovanni, A.
AU - Syriopoulos, K.
AU - Wessels, A.
AU - Stein, H. H.
N1 - Publisher Copyright:
© Wageningen Academic Publishers 2019
PY - 2019
Y1 - 2019
N2 - This experiment was conducted to test the hypothesis that increase of standardized ileal digestible (SID) Trp:Lys is needed in diets for growing pigs if the SID Leu:Lys exceeds the requirement to prevent drops in both plasma serotonin (PS) and hypothalamic serotonin (HS) concentrations and to maintain growth performance of animals. Nine diets were formulated using a 3×3 factorial treatment arrangement (100, 200 or 300% SID Leu:Lys and 18, 23 or 28% SID Trp:Lys), and 144 growing pigs (28.2±1.9 kg) were assigned to the 9 diets in a randomized complete block design. Initial and final body weight of pigs and daily feed provisions were recorded, and average daily gain (ADG), average daily feed intake (ADFI), and gain to feed ratio were calculated. On d 0, 11 and 21, blood samples were collected, and hypothalamus samples were collected on d 21. Data were analyzed using a response surface model by removing the terms in the model that were not significant. Interactions between SID Trp:Lys and SID Leu:Lys for ADG, ADFI, PS, and HS were observed. For prediction of ADG, ADFI, and HS, both positive linear SID Trp:Lys and SID Leu:Lys terms were included in each model. However, negative linear SID Trp:Lys and positive linear SID Leu:Lys terms were observed in the model for PS. In conclusion, increasing SID Trp:Lys in diets is needed to alleviate the negative impact of excess dietary Leu on growth performance and HS concentration of growing pigs.
AB - This experiment was conducted to test the hypothesis that increase of standardized ileal digestible (SID) Trp:Lys is needed in diets for growing pigs if the SID Leu:Lys exceeds the requirement to prevent drops in both plasma serotonin (PS) and hypothalamic serotonin (HS) concentrations and to maintain growth performance of animals. Nine diets were formulated using a 3×3 factorial treatment arrangement (100, 200 or 300% SID Leu:Lys and 18, 23 or 28% SID Trp:Lys), and 144 growing pigs (28.2±1.9 kg) were assigned to the 9 diets in a randomized complete block design. Initial and final body weight of pigs and daily feed provisions were recorded, and average daily gain (ADG), average daily feed intake (ADFI), and gain to feed ratio were calculated. On d 0, 11 and 21, blood samples were collected, and hypothalamus samples were collected on d 21. Data were analyzed using a response surface model by removing the terms in the model that were not significant. Interactions between SID Trp:Lys and SID Leu:Lys for ADG, ADFI, PS, and HS were observed. For prediction of ADG, ADFI, and HS, both positive linear SID Trp:Lys and SID Leu:Lys terms were included in each model. However, negative linear SID Trp:Lys and positive linear SID Leu:Lys terms were observed in the model for PS. In conclusion, increasing SID Trp:Lys in diets is needed to alleviate the negative impact of excess dietary Leu on growth performance and HS concentration of growing pigs.
KW - growth performance
KW - leucine
KW - pigs
KW - serotonin
KW - tryptophan
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U2 - 10.3920/978-90-8686-891-9_82
DO - 10.3920/978-90-8686-891-9_82
M3 - Article
AN - SCOPUS:85113786126
SN - 0071-2477
VL - 138
SP - 303
EP - 304
JO - EAAP Scientific Series
JF - EAAP Scientific Series
ER -