Effects of dermal application of 10.0% imidacloprid-0.08% ivermectin in ivermectin-sensitive Collies

Allan J. Paul, Douglas E. Hutchens, Lawrence D. Firkins, Coleen M. Keehan

Research output: Contribution to journalArticlepeer-review

Abstract

Objective - To evaluate the safety of dermal application of 10.0% imidacloprid-0.08% ivermectin in ivermectin-sensitive Collies at dose rates of 3 to 5 times the proposed maximum therapeutic dose. Animals - 15 Collies (5 males and 10 females) that were confirmed as ivermectin-sensitive dogs. Procedure - Dogs were assigned to 3 treatment groups (control, 3X, or 5X group) in a randomized block design on the basis of the maximal ivermectin-sensitivity score obtained during preliminary screening. Dogs in groups 3X and 5X were treated at 3 and 5 times the maximum label dose, respectively. Control dogs received an application of an equal volume of a nonmedicated solution. Observation and scoring on all days were conducted to specifically include neurologic signs typical of ivermectin toxicosis, including lethargy, ataxia, abnormal mydriasis, and abnormal salivation. Results - None of the dogs had clinical abnormalities during the study period. Conclusions and Clinical Relevance - Analysis of results of this study indicates that dermal application of 10.0% imidacloprid-0.08% ivermectin is safe for use in ivermectin-sensitive Collies at dose rates of 3 or 5 times the proposed maximum therapeutic dose.

Original languageEnglish (US)
Pages (from-to)277-278
Number of pages2
JournalAmerican journal of veterinary research
Volume65
Issue number3
DOIs
StatePublished - Mar 2004

ASJC Scopus subject areas

  • General Veterinary

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