Effects of cholesterol ester transfer protein (CETP) gene on adiposity in response to long-term overfeeding

Margarita Terán-García, Jean Pierre Després, Angelo Tremblay, Claude Bouchard

Research output: Contribution to journalArticlepeer-review

Abstract

Cholesterol ester transfer protein (CETP) plays a key role in remodeling triglyceride-rich particles and high-density lipoproteins (HDL). We investigated CETP sequence variants in response to long-term overfeeding (100 days) in 12 pairs of male monozygotic twins (mean age ± S.D.: 21 ± 2 years). Body fat mass (FM), abdominal subcutaneous (ASF) and visceral fat (AVF), and plasma lipoproteins were determined. The CETP variants C>T/In9 (rs289714) and G>A/Ex14 (rs5882, or I405V) were investigated by RFLP-PCR methodologies. Before overfeeding, the CETP CC/In9 (n = 18) genotype was associated with lower FM compared to the C>T/In9 heterozygotes. Overfeeding induced more FM and ASF accretion in C>T/In9 carriers (P ≤ 0.05). CETP V405V homozygotes (n = 8) had lower BMI, FM, and ASF before overfeeding than those with the I405I (n = 6) or I405V (n = 10) genotypes. However, V405V subjects had the largest gain in AVF with overfeeding (P = 0.02). Decreases from baseline were significantly different across the I405V genotypes for HDL-C, HDL-Apo AI, HDL2, and HDL3 (P ≤ 0.05). Our data suggests that CETP sequence variation contributes to the undesirable changes in adiposity and HDL-C levels when exposed to excessive calorie consumption and may be potentially helpful to identify individuals with the metabolic syndrome who are at higher risk of cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)455-460
Number of pages6
JournalAtherosclerosis
Volume196
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Keywords

  • Adiposity
  • CETP
  • HDL
  • Lipoprotein
  • Obesity
  • Overfeeding

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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