Effects of cholesterol and cholesterol derivatives on hydrocarbon chain mobility in lipids

E. Oldfield; D. Chapman

doi:10.1016/0006-291X(71)90658-9

Effects of cholesterol and cholesterol derivatives on hydrocarbon chain mobility in lipids

Research output: Contribution to journal › Article › peer-review

Abstract

Cholesterol inhibits the chain motion of egg yolk lecithin when it is in the liquid crystalline phase. It also removes the sharp transition from gel to liquid crystalline phase normally observed with a saturated lipid such as dipalmitoyl lecithin. A similar lipid state is produced, partially characterised by a spin probe correlation time τ_c∼2 × 10^-8s. Small modifications to the cholesterol structure cause marked alterations in the solubilisation properties of the resultant steroid in lecithin bilayer systems.

Original language	English (US)
Pages (from-to)	610-616
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(71)90658-9
State	Published - May 7 1971
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Effects of cholesterol and cholesterol derivatives on hydrocarbon chain mobility in lipids",

abstract = "Cholesterol inhibits the chain motion of egg yolk lecithin when it is in the liquid crystalline phase. It also removes the sharp transition from gel to liquid crystalline phase normally observed with a saturated lipid such as dipalmitoyl lecithin. A similar lipid state is produced, partially characterised by a spin probe correlation time τ c∼2 × 10-8s. Small modifications to the cholesterol structure cause marked alterations in the solubilisation properties of the resultant steroid in lecithin bilayer systems.",

author = "E. Oldfield and D. Chapman",

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AU - Chapman, D.

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AB - Cholesterol inhibits the chain motion of egg yolk lecithin when it is in the liquid crystalline phase. It also removes the sharp transition from gel to liquid crystalline phase normally observed with a saturated lipid such as dipalmitoyl lecithin. A similar lipid state is produced, partially characterised by a spin probe correlation time τ c∼2 × 10-8s. Small modifications to the cholesterol structure cause marked alterations in the solubilisation properties of the resultant steroid in lecithin bilayer systems.

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ER -

Effects of cholesterol and cholesterol derivatives on hydrocarbon chain mobility in lipids

Abstract

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