Effects of challenge with a virulent genotype II strain of porcine reproductive and respiratory syndrome virus on piglets vaccinated with an attenuated genotype I strain vaccine

M. Roca, M. Gimeno, S. Bruguera, J. Segalés, I. Díaz, I. J. Galindo-Cardiel, E. Martínez, L. Darwich, Y. Fang, J. Maldonado, R. March, E. Mateu

Research output: Contribution to journalArticle

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is endemic in most parts of Asia, where genotype I and II strains of diverse virulence may coexist. This study evaluated the outcome of infection with a highly virulent Asian genotype II PRRSV isolate in piglets vaccinated with a genotype I vaccine. Twenty-one 3-week-old piglets were divided in three groups: Pigs in group V (n=8) were vaccinated with an attenuated genotype I commercial PRRSV vaccine, while pigs in group U (n=8) and a control group (group C; n=5) were unvaccinated; 6weeks later, pigs in groups V and U were challenged intranasally with a highly virulent strain of genotype II PRRSV (1×105 50% tissue culture infectious doses/mL), while pigs in group C received a placebo. Over a period of 21days after challenge, vaccinated pigs had significantly lower mortality (0/8 versus 2/8), fewer days of fever, a lower frequency of catarrhal bronchopneumonia, higher weight gains (13.4 versus 6.6kg) and lower levels of viraemia compared to unvaccinated challenged pigs. Immunisation with a genotype I attenuated PRRSV vaccine provided partial protection against challenge with a highly virulent genotype II strain.

Original languageEnglish (US)
Pages (from-to)92-96
Number of pages5
JournalVeterinary Journal
Volume193
Issue number1
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

Keywords

  • Heterologous protection
  • Porcine reproductive and respiratory syndrome virus
  • Vaccination

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Roca, M., Gimeno, M., Bruguera, S., Segalés, J., Díaz, I., Galindo-Cardiel, I. J., Martínez, E., Darwich, L., Fang, Y., Maldonado, J., March, R., & Mateu, E. (2012). Effects of challenge with a virulent genotype II strain of porcine reproductive and respiratory syndrome virus on piglets vaccinated with an attenuated genotype I strain vaccine. Veterinary Journal, 193(1), 92-96. https://doi.org/10.1016/j.tvjl.2011.11.019