TY - JOUR
T1 - Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation
AU - Moussa, Issam
AU - Oetgen, Mathew
AU - Roubin, Gary
AU - Colombo, Antonio
AU - Wang, Xangdong
AU - Iyer, Sriram
AU - Maida, Roberta
AU - Collins, Michael
AU - Kreps, Edward
AU - Moses, Jeffrey W.
PY - 1999/5/11
Y1 - 1999/5/11
N2 - Background - Ticlopidine has been shown to reduce the incidence of stent thrombosis compared with warfarin, but it may cause serious hematological side effects. Clopidogrel, a new thienopyridine derivative, may be a safe alternative to ticlopidine. The aim of this study was to compare the safety and efficacy of clopidogrel and aspirin with those of ticlopidine and aspirin in patients undergoing coronary stent implantation. Methods and Results - The population of this study consisted of 2 groups: patients who underwent coronary stenting and were treated with ticlopidine and aspirin (TA group, n=1406), and patients who underwent coronary stenting followed by treatment with clopidogrel and aspirin (CA group, n=283). At 1-month follow-up, there was no difference in stem thrombosis (1.5% versus 1.4%, P=1.0) or major adverse cardiac events (3.1% versus 2.4%, P=0.85) between the TA and CA groups, respectively. The probability of any side effect (neutropenia, diarrhea, rash) was significantly higher in the TA group (10.6% versus 5.3%, P=0.006; relative risk, 0.53; CI, 0.32 to 0.86). Conclusions - These data suggest that clopidogrel may be an effective pharmacological regimen after coronary stent implantation. Furthermore, the simpler dosing regimen, the absence of neutropenia, and the lower frequency of other side effects make it a safe alternative to ticlopidine.
AB - Background - Ticlopidine has been shown to reduce the incidence of stent thrombosis compared with warfarin, but it may cause serious hematological side effects. Clopidogrel, a new thienopyridine derivative, may be a safe alternative to ticlopidine. The aim of this study was to compare the safety and efficacy of clopidogrel and aspirin with those of ticlopidine and aspirin in patients undergoing coronary stent implantation. Methods and Results - The population of this study consisted of 2 groups: patients who underwent coronary stenting and were treated with ticlopidine and aspirin (TA group, n=1406), and patients who underwent coronary stenting followed by treatment with clopidogrel and aspirin (CA group, n=283). At 1-month follow-up, there was no difference in stem thrombosis (1.5% versus 1.4%, P=1.0) or major adverse cardiac events (3.1% versus 2.4%, P=0.85) between the TA and CA groups, respectively. The probability of any side effect (neutropenia, diarrhea, rash) was significantly higher in the TA group (10.6% versus 5.3%, P=0.006; relative risk, 0.53; CI, 0.32 to 0.86). Conclusions - These data suggest that clopidogrel may be an effective pharmacological regimen after coronary stent implantation. Furthermore, the simpler dosing regimen, the absence of neutropenia, and the lower frequency of other side effects make it a safe alternative to ticlopidine.
KW - Clopidogrel
KW - Stents
KW - Ticlopidine
UR - http://www.scopus.com/inward/record.url?scp=0033545889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033545889&partnerID=8YFLogxK
U2 - 10.1161/01.CIR.99.18.2364
DO - 10.1161/01.CIR.99.18.2364
M3 - Article
C2 - 10318654
AN - SCOPUS:0033545889
SN - 0009-7322
VL - 99
SP - 2364
EP - 2366
JO - Circulation
JF - Circulation
IS - 18
ER -