Effective 3d viscoelasticity of red blood cells measured by diffraction phase microscopy

Ru Wang, Huafeng Ding, Mustafa Mir, Krishnarao Tangella, Gabriel Popescu

Research output: Contribution to journalArticlepeer-review

Abstract

We present optical measurements of nanoscale red blood cell fluctuations obtained by highly sensitive quantitative phase imaging. These spatio-temporal fluctuations are modeled in terms of the bulk viscoelastic response of the cell. Relating the displacement distribution to the storage and loss moduli of the bulk has the advantage of incorporating all geometric and cortical effects into a single effective medium behavior. The results on normal cells indicate that the viscous modulus is much larger than the elastic one throughout the entire frequency range covered by the measurement, indicating fluid behavior.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalBiomedical Optics Express
Volume2
Issue number3
DOIs
StatePublished - Mar 1 2011

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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