Effect of trimethoprim/sulfamethoxazole on thyroid function in dogs with pyoderma

I. A. Hall, K. L. Campbell, M. D. Chambers, C. N. Davis

Research output: Contribution to journalArticlepeer-review


The effect of trimethoprim/sulfamethoxazole (T/SMX, 30 mg/kg, PO, q 12 h for 6 weeks) on thyroid function was evaluated in 21 dogs with pyoderma and normal baseline serum thyroxine concentrations. The population mean serum thyroxine concentration, but not the population mean serum triiodothyronine concentration, was significantly decreased at the end of treatment. After 6 weeks of treatment, the response in 3 dogs to thyrotropin administration was substantially reduced. Radionuclide thyroid imaging of 2 dogs after T/SMX treatment revealed high-than-normal thyroid technetium 99m pertechnetate uptake, suggestive of an interference with iodide metabolism. Use of T/SMX may cause hypothyroidism, and inadequate thyroid function may be incorrectly diagnosed in dogs treated with this antimicrobial.

Original languageEnglish (US)
Pages (from-to)1959-1962
Number of pages4
JournalJournal of the American Veterinary Medical Association
Issue number12
StatePublished - 1993

ASJC Scopus subject areas

  • veterinary(all)


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