Effect of Trans, Trans-Farnesol on Pseudogymnoascus destructans and Several Closely Related Species

Daniel B. Raudabaugh, Andrew N. Miller

Research output: Contribution to journalArticlepeer-review


Bat white-nose syndrome, caused by the psychrophilic fungus Pseudogymnoascus destructans, has dramatically reduced the populations of many hibernating North American bat species. The search for effective biological control agents targeting P.destructans is of great importance. We report that the sesquiterpene trans, trans-farnesol, which is also a Candidaalbicans quorum sensing compound, prevented in vitro conidial germination for at least 14 days and inhibited growth of preexisting hyphae of five P. destructans isolates in filtered potato dextrose broth at 10 °C. Depending on the inoculation concentrations, both spore and hyphal inhibition occurred upon exposure to concentrations as low as 15–20 µM trans, trans-farnesol. In contrast, most North American Pseudogymnoascus isolates were more tolerant to the exposure of trans, trans-farnesol. Our results suggest that some Candida isolates may have the potential to inhibit the growth of P. destructans and that the sesquiterpene trans, trans-farnesol has the potential to be utilized as a biological control agent.

Original languageEnglish (US)
Pages (from-to)325-332
Number of pages8
Issue number5-6
StatePublished - Dec 1 2015


  • Biological control
  • Candida albicans quorum sensing compound
  • Sesquiterpene
  • White-nose syndrome

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology
  • Agronomy and Crop Science
  • veterinary (miscalleneous)


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