Effect of parenteral administration of ivermectin and erythromycin on abomasal emptying rate in suckling calves

Gholam Reza Afshari, Mohammad Nouri, Ebrahim Bani Hassan, Mohammad Reza Mokhber-Dezfooli, Peter D. Constable

Research output: Contribution to journalArticlepeer-review

Abstract

Objective - To evaluate the effect of parenteral administration of ivermectin and erythromycin on abomasal emptying rate in suckling calves. Animals - 6 male Holstein-Friesian calves < 15 days old. Procedures - In a crossover study, calves were administered each of 3 treatments (control treatment, 2 mL of saline [0.9% NaCl] solution, IM; erythromycin, 8.8 mg/kg, IM; and ivermectin, 200 μg/kg, IV). Thirty minutes later, calves were bottle-fed 2 L of fresh cow's milk containing acetaminophen (50 mg/kg). Blood samples were collected from a jugular vein at various periods after suckling of milk. Abomasal emptying rate was assessed by use of the time to pharmacokinetically determined maximal plasma acetaminophen concentration. Results - Administration of erythromycin and ivermectin caused a significant increase in abomasal emptying rate, compared with results for the control treatment, as determined on the basis of time to maximal plasma acetaminophen concentration. Conclusions and Clinical Rellevance - Parenteral administration of erythromycin and ivermectin increased the abomasal emptying rate. The macrolide erythromycin can be an effective prokinetic agent in calves and other animals. Ivermectin is classified as a macrolide but has a number of structural differences from erythromycin. The clinical importance of a slight increase in abomasal emptying rate after IV administration of ivermectin remains to be determined because ivermectin is only labeled for SC, oral, and topical administration.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
JournalAmerican journal of veterinary research
Volume70
Issue number4
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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