Effect of Intradialytic Oral Nutritional Supplementation with or without Exercise Improves Muscle Mass Quality and Physical Function in Hemodialysis Patients: A Pilot Study

Geovana Martin-Alemañy, Monserrat Perez-Navarro, Kenneth R. Wilund, Gloria García-Villalobos, Irma Gómez-Guerrero, Guillermo Cantú-Quintanilla, Miguel Angel Reyes-Caldelas, Angeles Espinosa-Cuevas, Galileo Escobedo, Mara Medeiros, Paul N. Bennett, Rafael Valdez-Ortiz

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Oral nutritional supplementation (ONS) with or without exercise (EX) could improve muscle mass (MM) in chronic kidney disease. METHODS: Patients were randomized into two groups: (1) ONS and (2) ONS + EX. Thigh muscle area (cm2) and intramuscular lipid content via attenuation were evaluated at baseline and 6 months with computed tomography (CT) to measure MM quantity and quality. Physical function was measured by six-minute walk test (6 MWT), gait speed, handgrip strength (HGS), and Time Up and Go test (TUG) at baseline and 3 and 6 months. RESULTS: The ONS group (n= 14) showed statistically significant improvement in gait speed and HGS; ONS + EX group (n = 10) showed differences in gait speed, in 6 MWT, and HGS. In the ANOVA (3 times × 2 groups), no differences were observed between groups. Greater effect sizes in favor to ONS + EX group were observed in the 6 MWT (d = 1.02) and TUG test (d = 0.63). Muscle quality at six months revealed a significant trend in favor of the EX-group (p = 0.054). CONCLUSIONS: Both groups had improved physical function, and greater effect sizes were seen in the ONS + EX group for the 6 MWT and TUG test. Neither MM quantity or quality was improved in either group.

Original languageEnglish (US)
JournalNutrients
Volume14
Issue number14
DOIs
StatePublished - Jul 19 2022

Keywords

  • hemodialysis oral nutritional supplementation
  • aerobic exercise
  • anaerobic exercise
  • muscle mass
  • physical function

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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