TY - JOUR
T1 - Effect of Intradialytic Oral Nutritional Supplementation with or without Exercise Improves Muscle Mass Quality and Physical Function in Hemodialysis Patients: A Pilot Study
AU - Martin-Alemañy, Geovana
AU - Perez-Navarro, Monserrat
AU - Wilund, Kenneth R.
AU - García-Villalobos, Gloria
AU - Gómez-Guerrero, Irma
AU - Cantú-Quintanilla, Guillermo
AU - Reyes-Caldelas, Miguel Angel
AU - Espinosa-Cuevas, Angeles
AU - Escobedo, Galileo
AU - Medeiros, Mara
AU - Bennett, Paul N.
AU - Valdez-Ortiz, Rafael
N1 - Funding Information:
This study was funded by a grant from the International Society of Nephrology Clinical Research Program awarded the day 1 August 2019. G.M.A. was supported by the National Council of Science and Technology (CONACYT), CVU 708803. School of Medicine, and Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/7/19
Y1 - 2022/7/19
N2 - BACKGROUND: Oral nutritional supplementation (ONS) with or without exercise (EX) could improve muscle mass (MM) in chronic kidney disease. METHODS: Patients were randomized into two groups: (1) ONS and (2) ONS + EX. Thigh muscle area (cm2) and intramuscular lipid content via attenuation were evaluated at baseline and 6 months with computed tomography (CT) to measure MM quantity and quality. Physical function was measured by six-minute walk test (6 MWT), gait speed, handgrip strength (HGS), and Time Up and Go test (TUG) at baseline and 3 and 6 months. RESULTS: The ONS group (n= 14) showed statistically significant improvement in gait speed and HGS; ONS + EX group (n = 10) showed differences in gait speed, in 6 MWT, and HGS. In the ANOVA (3 times × 2 groups), no differences were observed between groups. Greater effect sizes in favor to ONS + EX group were observed in the 6 MWT (d = 1.02) and TUG test (d = 0.63). Muscle quality at six months revealed a significant trend in favor of the EX-group (p = 0.054). CONCLUSIONS: Both groups had improved physical function, and greater effect sizes were seen in the ONS + EX group for the 6 MWT and TUG test. Neither MM quantity or quality was improved in either group.
AB - BACKGROUND: Oral nutritional supplementation (ONS) with or without exercise (EX) could improve muscle mass (MM) in chronic kidney disease. METHODS: Patients were randomized into two groups: (1) ONS and (2) ONS + EX. Thigh muscle area (cm2) and intramuscular lipid content via attenuation were evaluated at baseline and 6 months with computed tomography (CT) to measure MM quantity and quality. Physical function was measured by six-minute walk test (6 MWT), gait speed, handgrip strength (HGS), and Time Up and Go test (TUG) at baseline and 3 and 6 months. RESULTS: The ONS group (n= 14) showed statistically significant improvement in gait speed and HGS; ONS + EX group (n = 10) showed differences in gait speed, in 6 MWT, and HGS. In the ANOVA (3 times × 2 groups), no differences were observed between groups. Greater effect sizes in favor to ONS + EX group were observed in the 6 MWT (d = 1.02) and TUG test (d = 0.63). Muscle quality at six months revealed a significant trend in favor of the EX-group (p = 0.054). CONCLUSIONS: Both groups had improved physical function, and greater effect sizes were seen in the ONS + EX group for the 6 MWT and TUG test. Neither MM quantity or quality was improved in either group.
KW - hemodialysis oral nutritional supplementation
KW - aerobic exercise
KW - anaerobic exercise
KW - muscle mass
KW - physical function
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U2 - 10.3390/nu14142946
DO - 10.3390/nu14142946
M3 - Article
C2 - 35889902
SN - 2072-6643
VL - 14
JO - Nutrients
JF - Nutrients
IS - 14
M1 - 2946
ER -