Effect of distinct ECM microenvironments on the genome-wide chromatin accessibility and gene expression responses of hepatic stellate cells

Keyphrases

• Extracellular Matrix 100%
• Matrix Microenvironment 100%
• Gene Response 100%
• Chromatin Accessibility 100%
• Hepatic Stellate Cells 100%
• Hepatic Stellate Cell Activation 45%
• Microenvironment 36%
• CEBPB 36%
• HSD11B1 36%
• Cell Microarray 27%
• Non-alcoholic Fatty Liver Disease (NAFLD) 27%
• Single-cell ATAC-seq 27%
• Gene Expression 18%
• High-throughput 18%
• Adaptation Responses 18%
• Substrate Stiffness 18%
• Regulatory Factors 18%
• State Transition 18%
• Liver Disease 18%
• RNA Sequencing (RNA-seq) 18%
• SiRNA Knockdown 18%
• Extracellular Matrix Stiffness 18%
• Extracellular Matrix Deposition 18%
• Extracellular Matrix Remodeling 18%
• RNA-seq Analysis 18%
• Activation State 18%
• Phenotypic States 18%
• Liver Fibrosis 18%
• Controlled Reduction 18%
• Extracellular Substrates 18%
• Fibrogenic Markers 18%
• Extracellular Matrix Organization 9%
• Stiffness Matrix 9%
• Acetylation 9%
• RNA-sequencing Data 9%
• H3K9 Methylation 9%
• Matrix Condition 9%
• Cooperative Effects 9%
• High Enrichment 9%
• Gene Set Enrichment Analysis 9%
• Fibrosis-related Genes 9%
• H3K4 Methylation 9%

Biochemistry, Genetics and Molecular Biology

• Gene Expression 100%
• Hepatic Stellate Cell 100%
• RNA Sequence 31%
• Rigidity 18%
• Microarrays 18%
• Small Interfering RNA 12%
• Cell Activation 12%
• Fibrogenesis 12%
• Methylation 6%
• Acetylation 6%
• Gene Set Enrichment Analysis 6%