Effect of Different Local Vibration Frequencies on the Multiscale Regularity of Plantar Skin Blood Flow

Fuyuan Liao, Keying Zhang, Lingling Zhou, Yanni Chen, Jeannette Elliott, Yih-Kuen Jan

Research output: Contribution to journalArticlepeer-review


Local vibration has shown promise in improving skin blood flow (SBF). However, there is no consensus on the selection of the best vibration frequency. An important reason may be that previous studies utilized time- and frequency-domain parameters to characterize vibration-induced SBF responses. These parameters are unable to characterize the structural features of the SBF response to local vibrations, thus contributing to the inconsistent findings seen in vibration research. The objective of this study was to provide evidence that nonlinear dynamics of SBF responses would be an important aspect for assessing the effect of local vibration on SBF. Local vibrations at 100 Hz, 35 Hz, and 0 Hz (sham vibration) with an amplitude of 1 mm were randomly applied to the right first metatarsal head of 12 healthy participants for 10 min. SBF at the same site was measured for 10 min before and after local vibration. The degree of regularity of SBF was quantified using a multiscale sample entropy algorithm. The results showed that 100 Hz vibration significantly increased multiscale regularity of SBF but 35 Hz and 0 Hz (sham vibration) did not. The significant increase of regularity of SBF after 100 Hz vibration was mainly attributed to increased regularity of SBF oscillations within the frequency interval at 0.0095–0.15 Hz. These findings support the use of multiscale regularity to assess effectiveness of local vibration on improving skin blood flow.
Original languageEnglish (US)
Article number1288
Pages (from-to)1-12
Number of pages12
Issue number11
StatePublished - Nov 13 2020


  • local vibration
  • regularity
  • vibration frequency
  • skin blood flow
  • multiscale entropy
  • Vibration frequency
  • Multiscale entropy
  • Local vibration
  • Regularity
  • Skin blood flow

ASJC Scopus subject areas

  • Physics and Astronomy(all)


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