Effect of dietary manipulation on c-myc RNA expression in adipose tissue, muscle and liver of broiler chickens

Jong Won Kim, Daniel L. Fletcher, Dennis R. Campion, H. Rex Gaskins, Roger Dean

Research output: Contribution to journalArticle

Abstract

The effects of dietary restriction on the relative steady state levels of cellular myc (c-myc) mRNA in abdominal adipose tissue, breast muscle and liver of chickens were determined. Fasting was found to increase c-myc RNA expression in adipose tissue (p<0.01). This increase returned to normal levels after refeeding. Muscle and liver in fasted birds did not show changes in c-myc that differed from controls. Serum concentrations of glucose, triglyceride (TG), free fatty acids (FFA) and insulin-like growth factor (IGF-I) were compared to levels of c-myc found in control birds. In adipose tissue, c-myc levels were negatively correlated with serum glucose, TG and IGF-I, while in muscle a positive correlation with serum glucose and TG was found. Data suggest that c-myc is involved in the metabolic changes occurring in fat cells under fasting conditions.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume180
Issue number1
DOIs
StatePublished - Oct 15 1991
Externally publishedYes

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Keywords

  • FFA
  • IGF-I
  • TG
  • free fatty acids
  • insulin-like growth factor
  • triglyceride

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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