TY - JOUR
T1 - Effect of Chronic Ethanol Ingestion on Mitochondrial Protein Synthesis in Sinclair(S-l) Miniature Swine
AU - Burke, J. P.
AU - Tumbleson, M. E.
AU - Hicklin, K. W.
AU - Wilson, R. B.
PY - 1975/4
Y1 - 1975/4
N2 - The effect of chronic ethanol ingestion on hepatic mitochondrial protein synthesis in miniature swine was investigated. After 3 wk on test, there was no decrease in the rate of amino acid incorporation between livers of control and ethanol consuming pigs. After 6 wk on test, there was a 33% decrease in rate of hepatic mitochondrial membrane protein synthesis in livers of experimental pigs, as compared with controls. When analyzed by SDS-gel electrophoresis, a decrease in labeling of the 40,000 mol wt peak, from both whole membrane protein and proteolipid protein profiles, was observed for livers from ethanol consuming pigs as compared with controls.
AB - The effect of chronic ethanol ingestion on hepatic mitochondrial protein synthesis in miniature swine was investigated. After 3 wk on test, there was no decrease in the rate of amino acid incorporation between livers of control and ethanol consuming pigs. After 6 wk on test, there was a 33% decrease in rate of hepatic mitochondrial membrane protein synthesis in livers of experimental pigs, as compared with controls. When analyzed by SDS-gel electrophoresis, a decrease in labeling of the 40,000 mol wt peak, from both whole membrane protein and proteolipid protein profiles, was observed for livers from ethanol consuming pigs as compared with controls.
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U2 - 10.3181/00379727-148-38687
DO - 10.3181/00379727-148-38687
M3 - Article
C2 - 1129322
AN - SCOPUS:0016702753
SN - 1535-3702
VL - 148
SP - 1051
EP - 1056
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
IS - 4
ER -