Effect of chronic ethanol consumption on liver metabolites in Sinclair (S-1) miniature swine

D. F. Kusewitt, J. P. Burke, M. E. Tumbleson

Research output: Contribution to journalArticle

Abstract

1. 1. The nature and extent of changes in levels of liver metabolites, as a result of chronic ethanol consumption, were investigated using miniature swine as experimental subjects. 2. 2. Mean ethanol consumption was in excess of 6.0 g ethanol/kg body weight per day. 3. 3. Mean hepatic tissue concentrations of triglycerides, NADH and β-hydroxybutyrate, as well as the β-hydroxybutyrate/acetoacetate ratio, were greater for pigs fed ethanol than for controls. 4. 4. Mean hepatic tissue levels of glycogen and ATP, as well as the NAD+/NADH ratio and energy charge, were less for pigs fed ethanol than for controls.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalGeneral Pharmacology
Volume8
Issue number5-6
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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