Effect of chronic ethanol consumption on liver metabolites in Sinclair (S-1) miniature swine

D. F. Kusewitt, J. P. Burke, M. E. Tumbleson

Research output: Contribution to journalArticle

Abstract

1. 1. The nature and extent of changes in levels of liver metabolites, as a result of chronic ethanol consumption, were investigated using miniature swine as experimental subjects. 2. 2. Mean ethanol consumption was in excess of 6.0 g ethanol/kg body weight per day. 3. 3. Mean hepatic tissue concentrations of triglycerides, NADH and β-hydroxybutyrate, as well as the β-hydroxybutyrate/acetoacetate ratio, were greater for pigs fed ethanol than for controls. 4. 4. Mean hepatic tissue levels of glycogen and ATP, as well as the NAD+/NADH ratio and energy charge, were less for pigs fed ethanol than for controls.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalGeneral Pharmacology
Volume8
Issue number5-6
DOIs
StatePublished - 1977

Fingerprint

Miniature Swine
Ethanol
NAD
Liver
Hydroxybutyrates
Swine
Glycogen
Triglycerides
Adenosine Triphosphate
Body Weight

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of chronic ethanol consumption on liver metabolites in Sinclair (S-1) miniature swine. / Kusewitt, D. F.; Burke, J. P.; Tumbleson, M. E.

In: General Pharmacology, Vol. 8, No. 5-6, 1977, p. 335-339.

Research output: Contribution to journalArticle

@article{64ef26a94ca0492daa011fbd93dfc8d2,
title = "Effect of chronic ethanol consumption on liver metabolites in Sinclair (S-1) miniature swine",
abstract = "1. 1. The nature and extent of changes in levels of liver metabolites, as a result of chronic ethanol consumption, were investigated using miniature swine as experimental subjects. 2. 2. Mean ethanol consumption was in excess of 6.0 g ethanol/kg body weight per day. 3. 3. Mean hepatic tissue concentrations of triglycerides, NADH and β-hydroxybutyrate, as well as the β-hydroxybutyrate/acetoacetate ratio, were greater for pigs fed ethanol than for controls. 4. 4. Mean hepatic tissue levels of glycogen and ATP, as well as the NAD+/NADH ratio and energy charge, were less for pigs fed ethanol than for controls.",
author = "Kusewitt, {D. F.} and Burke, {J. P.} and Tumbleson, {M. E.}",
year = "1977",
doi = "10.1016/0306-3623(77)90010-6",
language = "English (US)",
volume = "8",
pages = "335--339",
journal = "Vascular Pharmacology",
issn = "1537-1891",
publisher = "Elsevier Inc.",
number = "5-6",

}

TY - JOUR

T1 - Effect of chronic ethanol consumption on liver metabolites in Sinclair (S-1) miniature swine

AU - Kusewitt, D. F.

AU - Burke, J. P.

AU - Tumbleson, M. E.

PY - 1977

Y1 - 1977

N2 - 1. 1. The nature and extent of changes in levels of liver metabolites, as a result of chronic ethanol consumption, were investigated using miniature swine as experimental subjects. 2. 2. Mean ethanol consumption was in excess of 6.0 g ethanol/kg body weight per day. 3. 3. Mean hepatic tissue concentrations of triglycerides, NADH and β-hydroxybutyrate, as well as the β-hydroxybutyrate/acetoacetate ratio, were greater for pigs fed ethanol than for controls. 4. 4. Mean hepatic tissue levels of glycogen and ATP, as well as the NAD+/NADH ratio and energy charge, were less for pigs fed ethanol than for controls.

AB - 1. 1. The nature and extent of changes in levels of liver metabolites, as a result of chronic ethanol consumption, were investigated using miniature swine as experimental subjects. 2. 2. Mean ethanol consumption was in excess of 6.0 g ethanol/kg body weight per day. 3. 3. Mean hepatic tissue concentrations of triglycerides, NADH and β-hydroxybutyrate, as well as the β-hydroxybutyrate/acetoacetate ratio, were greater for pigs fed ethanol than for controls. 4. 4. Mean hepatic tissue levels of glycogen and ATP, as well as the NAD+/NADH ratio and energy charge, were less for pigs fed ethanol than for controls.

UR - http://www.scopus.com/inward/record.url?scp=0017571132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017571132&partnerID=8YFLogxK

U2 - 10.1016/0306-3623(77)90010-6

DO - 10.1016/0306-3623(77)90010-6

M3 - Article

C2 - 203510

AN - SCOPUS:0017571132

VL - 8

SP - 335

EP - 339

JO - Vascular Pharmacology

JF - Vascular Pharmacology

SN - 1537-1891

IS - 5-6

ER -