Effect of butylated hydroxytoluene on the disposition of [14C]aflatoxin B1 in the lactating rat

M. Y. Fukayama; W. G. Helferich; D. P.H. Hsieh

doi:10.1016/0278-6915(84)90164-9

Effect of butylated hydroxytoluene on the disposition of [¹⁴C]aflatoxin B₁ in the lactating rat

M. Y. Fukayama, W. G. Helferich, D. P.H. Hsieh

Research output: Contribution to journal › Article › peer-review

Abstract

The distribution and metabolism of an ip dose of [¹⁴C]aflatoxin B₁ (AFB₁) were studied in lactating Sprague-Dawley rats fed for the previous 13 days on a diet containing 0.5% butylated hydroxytoluene (BHT). Compared with ingestion of a BHT-free diet, treatment with BHT increased the biotransmission of AFB₁ metabolites, predominantly aflatoxin M₁ (AFM₁), into the mammary gland and its content of milk, decreased AFB₁ binding to liver nuclear DNA and enhanced the excretion of water-soluble metabolites of AFB₁, all measured 6 hr after an oral dose of [¹⁴C]AFB₁. These changes are related to the induction by BHT of hepatic enzymes involved in the transformation and detoxification of AFB₁. The results suggest that exposure to BHT may protect the lactating animal from the carcinogenic effect of AFB₁ but may increase the risk of exposure of the newborn infant to the carcinogenic metabolite AFM₁.

Original language	English (US)
Pages (from-to)	857-860
Number of pages	4
Journal	Food and Chemical Toxicology
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/0278-6915(84)90164-9
State	Published - Nov 1984
Externally published	Yes

ASJC Scopus subject areas

Food Science
Toxicology

Online availability

10.1016/0278-6915(84)90164-9

Library availability

Discover UIUC Full Text

Cite this

@article{69bb35ffcc344cd096176ea3a4187aa3,

title = "Effect of butylated hydroxytoluene on the disposition of [14C]aflatoxin B1 in the lactating rat",

abstract = "The distribution and metabolism of an ip dose of [14C]aflatoxin B1 (AFB1) were studied in lactating Sprague-Dawley rats fed for the previous 13 days on a diet containing 0.5% butylated hydroxytoluene (BHT). Compared with ingestion of a BHT-free diet, treatment with BHT increased the biotransmission of AFB1 metabolites, predominantly aflatoxin M1 (AFM1), into the mammary gland and its content of milk, decreased AFB1 binding to liver nuclear DNA and enhanced the excretion of water-soluble metabolites of AFB1, all measured 6 hr after an oral dose of [14C]AFB1. These changes are related to the induction by BHT of hepatic enzymes involved in the transformation and detoxification of AFB1. The results suggest that exposure to BHT may protect the lactating animal from the carcinogenic effect of AFB1 but may increase the risk of exposure of the newborn infant to the carcinogenic metabolite AFM1.",

author = "Fukayama, {M. Y.} and Helferich, {W. G.} and Hsieh, {D. P.H.}",

year = "1984",

month = nov,

doi = "10.1016/0278-6915(84)90164-9",

language = "English (US)",

volume = "22",

pages = "857--860",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Limited",

number = "11",

}

TY - JOUR

T1 - Effect of butylated hydroxytoluene on the disposition of [14C]aflatoxin B1 in the lactating rat

AU - Fukayama, M. Y.

AU - Helferich, W. G.

AU - Hsieh, D. P.H.

PY - 1984/11

Y1 - 1984/11

N2 - The distribution and metabolism of an ip dose of [14C]aflatoxin B1 (AFB1) were studied in lactating Sprague-Dawley rats fed for the previous 13 days on a diet containing 0.5% butylated hydroxytoluene (BHT). Compared with ingestion of a BHT-free diet, treatment with BHT increased the biotransmission of AFB1 metabolites, predominantly aflatoxin M1 (AFM1), into the mammary gland and its content of milk, decreased AFB1 binding to liver nuclear DNA and enhanced the excretion of water-soluble metabolites of AFB1, all measured 6 hr after an oral dose of [14C]AFB1. These changes are related to the induction by BHT of hepatic enzymes involved in the transformation and detoxification of AFB1. The results suggest that exposure to BHT may protect the lactating animal from the carcinogenic effect of AFB1 but may increase the risk of exposure of the newborn infant to the carcinogenic metabolite AFM1.

AB - The distribution and metabolism of an ip dose of [14C]aflatoxin B1 (AFB1) were studied in lactating Sprague-Dawley rats fed for the previous 13 days on a diet containing 0.5% butylated hydroxytoluene (BHT). Compared with ingestion of a BHT-free diet, treatment with BHT increased the biotransmission of AFB1 metabolites, predominantly aflatoxin M1 (AFM1), into the mammary gland and its content of milk, decreased AFB1 binding to liver nuclear DNA and enhanced the excretion of water-soluble metabolites of AFB1, all measured 6 hr after an oral dose of [14C]AFB1. These changes are related to the induction by BHT of hepatic enzymes involved in the transformation and detoxification of AFB1. The results suggest that exposure to BHT may protect the lactating animal from the carcinogenic effect of AFB1 but may increase the risk of exposure of the newborn infant to the carcinogenic metabolite AFM1.

UR - http://www.scopus.com/inward/record.url?scp=0021732314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021732314&partnerID=8YFLogxK

U2 - 10.1016/0278-6915(84)90164-9

DO - 10.1016/0278-6915(84)90164-9

M3 - Article

C2 - 6437947

AN - SCOPUS:0021732314

SN - 0278-6915

VL - 22

SP - 857

EP - 860

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

IS - 11

ER -