Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study

O. K. Glass, B. A. Inman, G. Broadwater, K. S. Courneya, J. R. Mackey, S. Goruk, Erik Nelson, J. Jasper, C. J. Field, J. R. Bain, M. Muehlbauer, R. D. Stevens, M. D. Hirschey, L. W. Jones

Research output: Contribution to journalArticle

Abstract

Background: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours.Patients and Methods:Paired peripheral blood samples were obtained from 44 patients with solid tumours receiving cytotoxic therapy and synthetic erythropoietin (usual care; n=21) or usual care plus supervised aerobic training (n=23) for 12 weeks. Samples were characterised for changes in immune, cytokine and angiogenic factors, and metabolic intermediates. Aerobic training consisted of three supervised cycle ergometry sessions per week at 60% to 100% of peak oxygen consumption (VO 2peak), 30-45 min per session, for 12 weeks following a nonlinear prescription.Results:The between-group delta change in cardiopulmonary function was +4.1 ml kg-1 min-1, favouring aerobic training (P<0.05). Significant pre-post between-group differences for five cytokine and angiogenic factors (HGF, IL-4, macrophage inflammatory protein-1β (MIP-1β), vascular endothelial growth factor (VEGF), and TNF-) also favour the aerobic training group (P's<0.05). These reductions occurred in conjunction with nonsignificant group differences for T lymphocytes CD4 +, CD8 +, and CD8 +/CD45RA (P<0.10). For these factors, circulating concentrations generally increased from baseline to week 12 in the aerobic training group compared with decreases or no change in the usual care group. No significant changes in any metabolic intermediates were observed.Conclusions:Aerobic training alters host availability of select immune-inflammatory effectors in patients with solid tumours; larger confirmatory studies in more homogenous samples are warranted.

Original languageEnglish (US)
Pages (from-to)825-831
Number of pages7
JournalBritish Journal of Cancer
Volume112
Issue number5
DOIs
StatePublished - Mar 3 2015
Externally publishedYes

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Angiogenesis Inducing Agents
Neoplasms
Cytokines
Macrophage Inflammatory Proteins
Ergometry
Immunologic Factors
Erythropoietin
Oxygen Consumption
Interleukin-4
Vascular Endothelial Growth Factor A
Prescriptions
Exercise
T-Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Glass, O. K., Inman, B. A., Broadwater, G., Courneya, K. S., Mackey, J. R., Goruk, S., ... Jones, L. W. (2015). Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study. British Journal of Cancer, 112(5), 825-831. https://doi.org/10.1038/bjc.2014.662

Effect of aerobic training on the host systemic milieu in patients with solid tumours : An exploratory correlative study. / Glass, O. K.; Inman, B. A.; Broadwater, G.; Courneya, K. S.; Mackey, J. R.; Goruk, S.; Nelson, Erik; Jasper, J.; Field, C. J.; Bain, J. R.; Muehlbauer, M.; Stevens, R. D.; Hirschey, M. D.; Jones, L. W.

In: British Journal of Cancer, Vol. 112, No. 5, 03.03.2015, p. 825-831.

Research output: Contribution to journalArticle

Glass, OK, Inman, BA, Broadwater, G, Courneya, KS, Mackey, JR, Goruk, S, Nelson, E, Jasper, J, Field, CJ, Bain, JR, Muehlbauer, M, Stevens, RD, Hirschey, MD & Jones, LW 2015, 'Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study', British Journal of Cancer, vol. 112, no. 5, pp. 825-831. https://doi.org/10.1038/bjc.2014.662
Glass, O. K. ; Inman, B. A. ; Broadwater, G. ; Courneya, K. S. ; Mackey, J. R. ; Goruk, S. ; Nelson, Erik ; Jasper, J. ; Field, C. J. ; Bain, J. R. ; Muehlbauer, M. ; Stevens, R. D. ; Hirschey, M. D. ; Jones, L. W. / Effect of aerobic training on the host systemic milieu in patients with solid tumours : An exploratory correlative study. In: British Journal of Cancer. 2015 ; Vol. 112, No. 5. pp. 825-831.
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abstract = "Background: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours.Patients and Methods:Paired peripheral blood samples were obtained from 44 patients with solid tumours receiving cytotoxic therapy and synthetic erythropoietin (usual care; n=21) or usual care plus supervised aerobic training (n=23) for 12 weeks. Samples were characterised for changes in immune, cytokine and angiogenic factors, and metabolic intermediates. Aerobic training consisted of three supervised cycle ergometry sessions per week at 60{\%} to 100{\%} of peak oxygen consumption (VO 2peak), 30-45 min per session, for 12 weeks following a nonlinear prescription.Results:The between-group delta change in cardiopulmonary function was +4.1 ml kg-1 min-1, favouring aerobic training (P<0.05). Significant pre-post between-group differences for five cytokine and angiogenic factors (HGF, IL-4, macrophage inflammatory protein-1β (MIP-1β), vascular endothelial growth factor (VEGF), and TNF-) also favour the aerobic training group (P's<0.05). These reductions occurred in conjunction with nonsignificant group differences for T lymphocytes CD4 +, CD8 +, and CD8 +/CD45RA (P<0.10). For these factors, circulating concentrations generally increased from baseline to week 12 in the aerobic training group compared with decreases or no change in the usual care group. No significant changes in any metabolic intermediates were observed.Conclusions:Aerobic training alters host availability of select immune-inflammatory effectors in patients with solid tumours; larger confirmatory studies in more homogenous samples are warranted.",
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T1 - Effect of aerobic training on the host systemic milieu in patients with solid tumours

T2 - An exploratory correlative study

AU - Glass, O. K.

AU - Inman, B. A.

AU - Broadwater, G.

AU - Courneya, K. S.

AU - Mackey, J. R.

AU - Goruk, S.

AU - Nelson, Erik

AU - Jasper, J.

AU - Field, C. J.

AU - Bain, J. R.

AU - Muehlbauer, M.

AU - Stevens, R. D.

AU - Hirschey, M. D.

AU - Jones, L. W.

PY - 2015/3/3

Y1 - 2015/3/3

N2 - Background: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours.Patients and Methods:Paired peripheral blood samples were obtained from 44 patients with solid tumours receiving cytotoxic therapy and synthetic erythropoietin (usual care; n=21) or usual care plus supervised aerobic training (n=23) for 12 weeks. Samples were characterised for changes in immune, cytokine and angiogenic factors, and metabolic intermediates. Aerobic training consisted of three supervised cycle ergometry sessions per week at 60% to 100% of peak oxygen consumption (VO 2peak), 30-45 min per session, for 12 weeks following a nonlinear prescription.Results:The between-group delta change in cardiopulmonary function was +4.1 ml kg-1 min-1, favouring aerobic training (P<0.05). Significant pre-post between-group differences for five cytokine and angiogenic factors (HGF, IL-4, macrophage inflammatory protein-1β (MIP-1β), vascular endothelial growth factor (VEGF), and TNF-) also favour the aerobic training group (P's<0.05). These reductions occurred in conjunction with nonsignificant group differences for T lymphocytes CD4 +, CD8 +, and CD8 +/CD45RA (P<0.10). For these factors, circulating concentrations generally increased from baseline to week 12 in the aerobic training group compared with decreases or no change in the usual care group. No significant changes in any metabolic intermediates were observed.Conclusions:Aerobic training alters host availability of select immune-inflammatory effectors in patients with solid tumours; larger confirmatory studies in more homogenous samples are warranted.

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