Effect of administration route on FES uptake into MCF-7 tumors

Joanna B. Downer, Lynne A. Jones, John A. Katzenellenbogen, Michael J. Welch

Research output: Contribution to journalArticlepeer-review


We have observed that intraperitoneal administration of [18F]fluoroestradiol (FES), a radiolabeled estrogen receptor ligand, results in higher abdominal organ uptake and slower blood clearance than intravenous administration in female mice. In SCID mice bearing MCF-7 human tumors SC, IP administration resulted in tumor uptake that was only about one third that obtained with IV administration. Thus, the route of administration of a radiopharmaceutical for imaging or radiotherapy of a tumor in the abdomen, an ovarian tumor, for example, could have a profound effect on the efficiency and selectivity of delivery of the agent to the tumor.

Original languageEnglish (US)
Pages (from-to)397-399
Number of pages3
JournalNuclear Medicine and Biology
Issue number4
StatePublished - 2001


  • Administration route
  • FES
  • MCF-7
  • Radiolabeled steroids

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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