TY - JOUR
T1 - Effect of administration route on FES uptake into MCF-7 tumors
AU - Downer, Joanna B.
AU - Jones, Lynne A.
AU - Katzenellenbogen, John A.
AU - Welch, Michael J.
N1 - Funding Information:
The authors acknowledge the following sources of funding: U.S. Department of Energy DE-FG02-84ER60218 (MJW) and National Institutes of Health P01 HL13851 (MJW). Also, a special thanks to Margaret V. Lanahan for preparing the FES.
PY - 2001
Y1 - 2001
N2 - We have observed that intraperitoneal administration of [18F]fluoroestradiol (FES), a radiolabeled estrogen receptor ligand, results in higher abdominal organ uptake and slower blood clearance than intravenous administration in female mice. In SCID mice bearing MCF-7 human tumors SC, IP administration resulted in tumor uptake that was only about one third that obtained with IV administration. Thus, the route of administration of a radiopharmaceutical for imaging or radiotherapy of a tumor in the abdomen, an ovarian tumor, for example, could have a profound effect on the efficiency and selectivity of delivery of the agent to the tumor.
AB - We have observed that intraperitoneal administration of [18F]fluoroestradiol (FES), a radiolabeled estrogen receptor ligand, results in higher abdominal organ uptake and slower blood clearance than intravenous administration in female mice. In SCID mice bearing MCF-7 human tumors SC, IP administration resulted in tumor uptake that was only about one third that obtained with IV administration. Thus, the route of administration of a radiopharmaceutical for imaging or radiotherapy of a tumor in the abdomen, an ovarian tumor, for example, could have a profound effect on the efficiency and selectivity of delivery of the agent to the tumor.
KW - Administration route
KW - FES
KW - MCF-7
KW - Radiolabeled steroids
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U2 - 10.1016/S0969-8051(01)00204-9
DO - 10.1016/S0969-8051(01)00204-9
M3 - Article
C2 - 11395312
AN - SCOPUS:0034995170
SN - 0969-8051
VL - 28
SP - 397
EP - 399
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
IS - 4
ER -