Ecotoxicology of phenylphosphonothioates

B. M. Francis, L. G. Hansen, T. R. Fukuto

Research output: Contribution to journalArticlepeer-review


The phenylphosphonothioate insecticides EPN and leptophos, and several analogs, were evaluated with respect to their delayed neurotoxic effects in hens and their environmental behavior in a terrestrial-aquatic model ecosystem. Acute toxicity to insects was highly correlated with Σσ of the substituted phenyl group (regression coefficient r = -0.91) while acute toxicity to mammals was slightly less well correlated (regression coefficient r = -0.71), and neurotoxicity was poorly correlated with Σσ (regression coefficient r = -0.35). Both EPN and leptophos were markedly more persistent and bioaccumulative in the model ecosystem than parathion. Desbromoleptophos, a contaminant and metabolite of leptophos, was seen to be highly stable and persistent terminal residue of leptophos.

Original languageEnglish (US)
Pages (from-to)187-195
Number of pages9
JournalEnvironmental health perspectives
VolumeVol. 36
StatePublished - 1980

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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