Ecoresorbable and bioresorbable microelectromechanical systems

Quansan Yang, Tzu Li Liu, Yeguang Xue, Heling Wang, Yameng Xu, Bashar Emon, Mingzheng Wu, Corey Rountree, Tong Wei, Irawati Kandela, Chad R. Haney, Anlil Brikha, Iwona Stepien, Jessica Hornick, Rebecca A. Sponenburg, Christina Cheng, Lauren Ladehoff, Yitong Chen, Ziying Hu, Changsheng WuMengdi Han, John M. Torkelson, Yevgenia Kozorovitskiy, M. Taher A. Saif, Yonggang Huang, Jan Kai Chang, John A. Rogers

Research output: Contribution to journalArticlepeer-review


Microelectromechanical systems (MEMS) are essential components in many electronic technologies for consumer and industrial applications. Such devices are typically made using materials selected to support long operational lifetimes, but MEMS designed to physically disintegrate or to dissolve after a targeted period could provide a route to reduce electronic waste and could enable applications that require a finite operating timeframe, such as temporary medical implants. Here we report ecoresorbable and bioresorbable MEMS that are based on fully water-soluble material platforms and can either naturally resorb into the environment to eliminate solid waste or in the body to avoid a need for surgical extraction. We illustrate the biocompatibility of the approach with mechanobiology, histology and haematology studies of the implanted devices and their dissolution end products. We also demonstrate bioresorbable encapsulating materials and deployment strategies in small animal models to reduce device damage, confine mobile fragments and provide robust adhesion with adjacent tissues.

Original languageEnglish (US)
Pages (from-to)526-538
Number of pages13
JournalNature Electronics
Issue number8
StatePublished - Aug 2022

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Electrical and Electronic Engineering


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