Ecological significance of induction of broad-substrate cytochrome p450s by natural and synthetic inducers in Helicoverpa Zea

Zhimou Wen, Ren Sen Zeng, Guodong Niu, May R Berenbaum, Mary A Schuler

Research output: Contribution to journalArticle

Abstract

The polyphagous corn earworm Helicoverpa zea relies on cytochrome P450 monooxygenases with broad substrate specificities to cope with the wide diversity of phytochemicals it encounters among its numerous host plants. These enzymes also contribute to the ability of this insect to tolerate toxins from sources other than its hosts, including microbial and synthetic toxins. Although upregulation of xenobiotic-metabolizing P450s in some herbivorous insects is closely linked to host plant toxins, transcriptional and/or post-transcriptional regulation of detoxification in this polyphagous species also appears to be relatively unspecialized. Reverse transcription polymerase chain reaction and metabolic analyses indicate that rare and infrequently encountered phytochemicals, as well as synthetic substances, can enhance metabolic activity in an adaptive fashion against both natural and synthetic toxins.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalJournal of Chemical Ecology
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2009

Fingerprint

Helicoverpa zea
Phytochemicals
Cytochromes
cytochromes
toxin
Zea mays
cytochrome
Insects
toxins
substrate
Detoxification
phytopharmaceuticals
Polymerase chain reaction
Xenobiotics
Substrates
Transcription
host plants
Substrate Specificity
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System

Keywords

  • Cytochrome P450 monooxygenases (P450s)
  • Helicoverpa zea
  • Plant-insect interactions
  • Transcriptional regulation

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry

Cite this

Ecological significance of induction of broad-substrate cytochrome p450s by natural and synthetic inducers in Helicoverpa Zea. / Wen, Zhimou; Zeng, Ren Sen; Niu, Guodong; Berenbaum, May R; Schuler, Mary A.

In: Journal of Chemical Ecology, Vol. 35, No. 2, 01.02.2009, p. 183-189.

Research output: Contribution to journalArticle

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