Earth BioGenome Project: Sequencing life for the future of life

Harris A. Lewin, Gene E. Robinson, W. John Kress, William J. Baker, Jonathan Coddington, Keith A. Crandall, Richard Durbin, Scott V. Edwards, Félix Forest, M. Thomas P. Gilbert, Melissa M. Goldstein, Igor V. Grigoriev, Kevin J. Hackett, David Haussler, Erich D. Jarvis, Warren E. Johnson, Aristides Patrinos, Stephen Richards, Juan Carlos Castilla-Rubio, Marie Anne Van SluysPamela S. Soltis, Xun Xu, Huanming Yang, Guojie Zhang

Research output: Contribution to journalReview article

Abstract

Increasing our understanding of Earth's biodiversity and responsibly stewarding its resources are among the most crucial scientific and social challenges of the new millennium. These challenges require fundamental new knowledge of the organization, evolution, functions, and interactions among millions of the planet's organisms. Herein, we present a perspective on the Earth BioGenome Project (EBP), a moonshot for biology that aims to sequence, catalog, and characterize the genomes of all of Earth's eukaryotic biodiversity over a period of 10 years. The outcomes of the EBP will inform a broad range of major issues facing humanity, such as the impact of climate change on biodiversity, the conservation of endangered species and ecosystems, and the preservation and enhancement of ecosystem services. We describe hurdles that the project faces, including data-sharing policies that ensure a permanent, freely available resource for future scientific discovery while respecting access and benefit sharing guidelines of the Nagoya Protocol. We also describe scientific and organizational challenges in executing such an ambitious project, and the structure proposed to achieve the project's goals. The far-reaching potential benefits of creating an open digital repository of genomic information for life on Earth can be realized only by a coordinated international effort.

Original languageEnglish (US)
Pages (from-to)4325-4333
Number of pages9
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number17
DOIs
StatePublished - Apr 24 2018

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Biodiversity
Ecosystem
Planets
Endangered Species
Information Dissemination
Climate Change
Organizations
Genome
Guidelines

Keywords

  • Access and benefit sharing
  • Biodiversity
  • Data science
  • Genome sequencing
  • Genomics

ASJC Scopus subject areas

  • General

Cite this

Earth BioGenome Project : Sequencing life for the future of life. / Lewin, Harris A.; Robinson, Gene E.; Kress, W. John; Baker, William J.; Coddington, Jonathan; Crandall, Keith A.; Durbin, Richard; Edwards, Scott V.; Forest, Félix; Gilbert, M. Thomas P.; Goldstein, Melissa M.; Grigoriev, Igor V.; Hackett, Kevin J.; Haussler, David; Jarvis, Erich D.; Johnson, Warren E.; Patrinos, Aristides; Richards, Stephen; Castilla-Rubio, Juan Carlos; Van Sluys, Marie Anne; Soltis, Pamela S.; Xu, Xun; Yang, Huanming; Zhang, Guojie.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 17, 24.04.2018, p. 4325-4333.

Research output: Contribution to journalReview article

Lewin, HA, Robinson, GE, Kress, WJ, Baker, WJ, Coddington, J, Crandall, KA, Durbin, R, Edwards, SV, Forest, F, Gilbert, MTP, Goldstein, MM, Grigoriev, IV, Hackett, KJ, Haussler, D, Jarvis, ED, Johnson, WE, Patrinos, A, Richards, S, Castilla-Rubio, JC, Van Sluys, MA, Soltis, PS, Xu, X, Yang, H & Zhang, G 2018, 'Earth BioGenome Project: Sequencing life for the future of life', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 17, pp. 4325-4333. https://doi.org/10.1073/pnas.1720115115
Lewin, Harris A. ; Robinson, Gene E. ; Kress, W. John ; Baker, William J. ; Coddington, Jonathan ; Crandall, Keith A. ; Durbin, Richard ; Edwards, Scott V. ; Forest, Félix ; Gilbert, M. Thomas P. ; Goldstein, Melissa M. ; Grigoriev, Igor V. ; Hackett, Kevin J. ; Haussler, David ; Jarvis, Erich D. ; Johnson, Warren E. ; Patrinos, Aristides ; Richards, Stephen ; Castilla-Rubio, Juan Carlos ; Van Sluys, Marie Anne ; Soltis, Pamela S. ; Xu, Xun ; Yang, Huanming ; Zhang, Guojie. / Earth BioGenome Project : Sequencing life for the future of life. In: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Vol. 115, No. 17. pp. 4325-4333.
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