TY - JOUR
T1 - Early time-restricted eating improves markers of cardiometabolic health but has no impact on intestinal nutrient absorption in healthy adults
AU - Dawson, M. Alan
AU - Cheung, Susan N.
AU - La Frano, Michael R.
AU - Nagpal, Ravinder
AU - Berryman, Claire E.
N1 - This study was supported by a planning grant from the FSU Council on Research and Creativity and the 2021 Herbalife Nutrition Scholarship. We thank Rob Fanter from the College of Agriculture Food and Environmental Sciences, California Polytechnic State University, San Luis Obispo, CA, USA for LC-MS analysis. We thank the study participants and members of the FSU Nutritional Physiology lab (Dr. Stephen Hennigar, Cedric Torres, Kate Miller, Kallie Dawkins, Dr. Nate De Jong, Sydney Siegel, and Paul Baker) for their dedication to this project. We would like to thank Dr. Joselyn N. Allen, founder and owner of SynSciComm LLC, for generating the graphical abstract.
This study was supported by a planning grant from the FSU Council on Research and Creativity and the 2021 Herbalife Nutrition Scholarship. We thank Rob Fanter from the College of Agriculture Food and Environmental Sciences, California Polytechnic State University, San Luis Obispo, CA, USA for LC-MS analysis. We thank the study participants and members of the FSU Nutritional Physiology lab (Dr. Stephen Hennigar, Cedric Torres, Kate Miller, Kallie Dawkins, Dr. Nate De Jong, Sydney Siegel, and Paul Baker) for their dedication to this project. We would like to thank Dr. Joselyn N. Allen, founder and owner of SynSciComm LLC, for generating the graphical abstract. Conceptualization, M.A.D. and C.E.B.; methodology, M.A.D. S.N.C. M.R.L.F. R.N. and C.E.B.; investigation, M.A.D. S.N.C. M.R.L.F. R.N. and C.E.B.; writing – original draft, M.A.D.; writing – review & editing, M.A.D. S.N.C. M.R.L.F. R.N. and C.E.B.; resources, C.E.B.; supervision, C.E.B.; funding acquisition, M.A.D. and C.E.B. The authors declare no competing interests.
PY - 2024/1/16
Y1 - 2024/1/16
N2 - Early time-restricted eating (eTRE) improves aspects of cardiometabolic health. Although the circadian system appears to regulate nutrient absorption, little is known about the effects of eTRE on intestinal absorption. In this randomized crossover trial, 16 healthy adults follow a controlled, weight maintenance diet for 9 days, consuming all calories between 0800 and 1400 (eTRE schedule) or 0800 and 2000 (control schedule). We measure the energy content of the diet, stool, and urine with bomb calorimetry and calculate intestinal energy absorption. The eTRE schedule is more effective than the control eating schedule for improving markers of cardiometabolic health, including 24-h mean glucose concentrations and glycemic variability, assessed as the mean amplitude of glycemic excursions. However, eTRE has no effect on intestinal energy and macronutrient absorption, gastrointestinal transit time, colonic hydrogen gas production, or stool microbial composition, suggesting eTRE does not impact gastrointestinal function. This trial is registered (ClinicalTrials.gov: NCT04877262).
AB - Early time-restricted eating (eTRE) improves aspects of cardiometabolic health. Although the circadian system appears to regulate nutrient absorption, little is known about the effects of eTRE on intestinal absorption. In this randomized crossover trial, 16 healthy adults follow a controlled, weight maintenance diet for 9 days, consuming all calories between 0800 and 1400 (eTRE schedule) or 0800 and 2000 (control schedule). We measure the energy content of the diet, stool, and urine with bomb calorimetry and calculate intestinal energy absorption. The eTRE schedule is more effective than the control eating schedule for improving markers of cardiometabolic health, including 24-h mean glucose concentrations and glycemic variability, assessed as the mean amplitude of glycemic excursions. However, eTRE has no effect on intestinal energy and macronutrient absorption, gastrointestinal transit time, colonic hydrogen gas production, or stool microbial composition, suggesting eTRE does not impact gastrointestinal function. This trial is registered (ClinicalTrials.gov: NCT04877262).
KW - cardiometabolic health
KW - chrononutrition
KW - digestibility
KW - early time-restricted eating
KW - metabolizable energy
KW - nutrient absorption
UR - http://www.scopus.com/inward/record.url?scp=85182383780&partnerID=8YFLogxK
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U2 - 10.1016/j.xcrm.2023.101363
DO - 10.1016/j.xcrm.2023.101363
M3 - Article
C2 - 38232698
AN - SCOPUS:85182383780
SN - 2666-3791
VL - 5
JO - Cell Reports Medicine
JF - Cell Reports Medicine
IS - 1
M1 - 101363
ER -