Early-life nutrition and neurodevelopment: Use of the piglet as a translational model

Austin T. Mudd, Ryan Neil Dilger

Research output: Contribution to journalReview article

Abstract

Optimal nutrition early in life is critical to ensure proper structural and functional development of infant organ systems. Although pediatric nutrition historically has emphasized research on the relation between nutrition, growth rates, and gastrointestinal maturation, efforts increasingly have focused on how nutrition influences neurodevelopment. The provision of human milk is considered the gold standard in pediatric nutrition; thus, there is interest in understanding how functional nutrients and bioactive components in milk may modulate developmental processes. The piglet has emerged as an important translational model for studying neurodevelopmental outcomes influenced by pediatric nutrition. Given the comparable nutritional requirements and strikingly similar brain developmental patterns between young pigs and humans, the piglet is being used increasingly in developmental nutritional neuroscience studies. The piglet primarily has been used to assess the effects of dietary fatty acids and their accretion in the brain throughout neurodevelopment. However, recent research indicates that other dietary components, including choline, iron, cholesterol, gangliosides, and sialic acid, among other compounds, also affect neurodevelopment in the pig model. Moreover, novel analytical techniques, including but not limited to MRI, behavioral assessments, and molecular quantification, allow for a more holistic understanding of how nutrition affects neurodevelopmental patterns. By combining early-life nutritional interventions with innovative analytical approaches, opportunities abound to quantify factors affecting neurodevelopmental trajectories in the neonate. This review discusses research using the translational pig model with primary emphasis on early-life nutrition interventions assessing neurodevelopment outcomes, while also discussing nutritionally-sensitive methods to characterize brain maturation.

Original languageEnglish (US)
Pages (from-to)92-104
Number of pages13
JournalAdvances in Nutrition
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

neurodevelopment
child nutrition
piglets
Swine
Pediatrics
nutrition
nutritional intervention
Brain
brain
swine
Nutritional Requirements
Translational Medical Research
Gangliosides
N-Acetylneuraminic Acid
Human Milk
Neurosciences
Child Development
infant development
Choline
Research

Keywords

  • Animal model
  • Early-life nutrition
  • Magnetic resonance imaging
  • Neurodevelopment
  • Pediatric nutrition
  • Piglet

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Early-life nutrition and neurodevelopment : Use of the piglet as a translational model. / Mudd, Austin T.; Dilger, Ryan Neil.

In: Advances in Nutrition, Vol. 8, No. 1, 01.01.2017, p. 92-104.

Research output: Contribution to journalReview article

@article{4e9fd556d7394531ba3a0ae6c680a8bc,
title = "Early-life nutrition and neurodevelopment: Use of the piglet as a translational model",
abstract = "Optimal nutrition early in life is critical to ensure proper structural and functional development of infant organ systems. Although pediatric nutrition historically has emphasized research on the relation between nutrition, growth rates, and gastrointestinal maturation, efforts increasingly have focused on how nutrition influences neurodevelopment. The provision of human milk is considered the gold standard in pediatric nutrition; thus, there is interest in understanding how functional nutrients and bioactive components in milk may modulate developmental processes. The piglet has emerged as an important translational model for studying neurodevelopmental outcomes influenced by pediatric nutrition. Given the comparable nutritional requirements and strikingly similar brain developmental patterns between young pigs and humans, the piglet is being used increasingly in developmental nutritional neuroscience studies. The piglet primarily has been used to assess the effects of dietary fatty acids and their accretion in the brain throughout neurodevelopment. However, recent research indicates that other dietary components, including choline, iron, cholesterol, gangliosides, and sialic acid, among other compounds, also affect neurodevelopment in the pig model. Moreover, novel analytical techniques, including but not limited to MRI, behavioral assessments, and molecular quantification, allow for a more holistic understanding of how nutrition affects neurodevelopmental patterns. By combining early-life nutritional interventions with innovative analytical approaches, opportunities abound to quantify factors affecting neurodevelopmental trajectories in the neonate. This review discusses research using the translational pig model with primary emphasis on early-life nutrition interventions assessing neurodevelopment outcomes, while also discussing nutritionally-sensitive methods to characterize brain maturation.",
keywords = "Animal model, Early-life nutrition, Magnetic resonance imaging, Neurodevelopment, Pediatric nutrition, Piglet",
author = "Mudd, {Austin T.} and Dilger, {Ryan Neil}",
year = "2017",
month = "1",
day = "1",
doi = "10.3945/an.116.013243",
language = "English (US)",
volume = "8",
pages = "92--104",
journal = "Advances in nutrition (Bethesda, Md.)",
issn = "2161-8313",
publisher = "American Society for Nutrition",
number = "1",

}

TY - JOUR

T1 - Early-life nutrition and neurodevelopment

T2 - Use of the piglet as a translational model

AU - Mudd, Austin T.

AU - Dilger, Ryan Neil

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Optimal nutrition early in life is critical to ensure proper structural and functional development of infant organ systems. Although pediatric nutrition historically has emphasized research on the relation between nutrition, growth rates, and gastrointestinal maturation, efforts increasingly have focused on how nutrition influences neurodevelopment. The provision of human milk is considered the gold standard in pediatric nutrition; thus, there is interest in understanding how functional nutrients and bioactive components in milk may modulate developmental processes. The piglet has emerged as an important translational model for studying neurodevelopmental outcomes influenced by pediatric nutrition. Given the comparable nutritional requirements and strikingly similar brain developmental patterns between young pigs and humans, the piglet is being used increasingly in developmental nutritional neuroscience studies. The piglet primarily has been used to assess the effects of dietary fatty acids and their accretion in the brain throughout neurodevelopment. However, recent research indicates that other dietary components, including choline, iron, cholesterol, gangliosides, and sialic acid, among other compounds, also affect neurodevelopment in the pig model. Moreover, novel analytical techniques, including but not limited to MRI, behavioral assessments, and molecular quantification, allow for a more holistic understanding of how nutrition affects neurodevelopmental patterns. By combining early-life nutritional interventions with innovative analytical approaches, opportunities abound to quantify factors affecting neurodevelopmental trajectories in the neonate. This review discusses research using the translational pig model with primary emphasis on early-life nutrition interventions assessing neurodevelopment outcomes, while also discussing nutritionally-sensitive methods to characterize brain maturation.

AB - Optimal nutrition early in life is critical to ensure proper structural and functional development of infant organ systems. Although pediatric nutrition historically has emphasized research on the relation between nutrition, growth rates, and gastrointestinal maturation, efforts increasingly have focused on how nutrition influences neurodevelopment. The provision of human milk is considered the gold standard in pediatric nutrition; thus, there is interest in understanding how functional nutrients and bioactive components in milk may modulate developmental processes. The piglet has emerged as an important translational model for studying neurodevelopmental outcomes influenced by pediatric nutrition. Given the comparable nutritional requirements and strikingly similar brain developmental patterns between young pigs and humans, the piglet is being used increasingly in developmental nutritional neuroscience studies. The piglet primarily has been used to assess the effects of dietary fatty acids and their accretion in the brain throughout neurodevelopment. However, recent research indicates that other dietary components, including choline, iron, cholesterol, gangliosides, and sialic acid, among other compounds, also affect neurodevelopment in the pig model. Moreover, novel analytical techniques, including but not limited to MRI, behavioral assessments, and molecular quantification, allow for a more holistic understanding of how nutrition affects neurodevelopmental patterns. By combining early-life nutritional interventions with innovative analytical approaches, opportunities abound to quantify factors affecting neurodevelopmental trajectories in the neonate. This review discusses research using the translational pig model with primary emphasis on early-life nutrition interventions assessing neurodevelopment outcomes, while also discussing nutritionally-sensitive methods to characterize brain maturation.

KW - Animal model

KW - Early-life nutrition

KW - Magnetic resonance imaging

KW - Neurodevelopment

KW - Pediatric nutrition

KW - Piglet

UR - http://www.scopus.com/inward/record.url?scp=85011309200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011309200&partnerID=8YFLogxK

U2 - 10.3945/an.116.013243

DO - 10.3945/an.116.013243

M3 - Review article

C2 - 28096130

AN - SCOPUS:85011309200

VL - 8

SP - 92

EP - 104

JO - Advances in nutrition (Bethesda, Md.)

JF - Advances in nutrition (Bethesda, Md.)

SN - 2161-8313

IS - 1

ER -