Early detection of fatty liver disease in mice via quantitative ultrasound

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nonalcoholic fatty liver disease (NAFLD) is estimated to have a 25-30% incidence among obese individuals and can lead to inflammation (nonalcoholic steatohepatitis, NASH) and fibrosis. While conventional ultrasound and other imaging techniques can diagnose advanced stages of fatty liver and hepatic cirrhosis (one NASH outcome), even though pathology is the gold standard, existing techniques are not currently able to detect early stages of NAFLD. The objective is to develop a method for early detection of NAFLD in humans by first examining the model-free quantitative ultrasound (QUS) parameters of livers in diet-controlled mice. Two studies were conducted, each with 25 male C57BL/6J mice; 20 fed an atherogenic (Ath) diet and 5 fed a control diet. In Study 1 (a non-QUS study), 10 mice each were fed the Ath diet for 4 and 8 weeks, respectively; there was significant liver steatosis and inflammation of the Ath-diet-fed mice. Therefore, Study 2 was conducted with reduced feeding times to moderate the Ath diet's liver effect for which 10 mice each were on the Ath diet for 2 and 4 weeks, respectively. For Study 2, liver lipids compared somewhat favorably to pathologist steatosis grades. QUS model-free parameters were functionally related to liver lipids. These preliminary findings suggest that early detection of NAFLD is feasible with QUS.

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
PublisherIEEE Computer Society
Pages2363-2366
Number of pages4
ISBN (Electronic)9781479970490
DOIs
StatePublished - Oct 20 2014
Event2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: Sep 3 2014Sep 6 2014

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2014 IEEE International Ultrasonics Symposium, IUS 2014
CountryUnited States
CityChicago
Period9/3/149/6/14

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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