Early detection of extravascular lung water in an inhalation injury animal model

A rabbit inhalation injury model, and a dual tracer radioactive isotope technique (Rowland et al., 1986), have been utilized with small- and medium-sized towards normal values some time within 24h if fluid 2 h after smoke inhalation or fluid resuscitation and especially with the combination of inhalation injury and fluid resuscitation. This oedema appears to have decreased by 24 h post-injury. There does not appear to be any difference between the small- and medium-sized tracers in the transit times of tracer in the lung vascular compartment. The increases in extravascular water volume have been confirmed by gravimetric analyses of the lungs. Thus the pulmonary oedema in the rabbit animal model is detectable within 2 h post-injury, with a return towards normal values some time within 24h if fluid challenged for short periods. Fluid resuscitation exacerbates the amount of oedema that developed. The onset of pulmonary oedema may therefore be earlier than previously seen clinically, and fluid resuscitation modifications may be of benefit in smoke inhalation injury.