Dynamics of chromatin, proteins, and bodies within the cell nucleus

Research output: Contribution to journalReview article

Abstract

A new and still evolving paradigm of a highly dynamic nucleus has emerged in recent years. This paradigm includes an inherently high turnover rate of histone and non-histone protein modifications, targeted turnover and/or displacement of 'stable' core histone proteins, constant flux of macromolecules through chromosomes and nuclear bodies, including transcription factors and co-activators, and an energy-dependent facilitation of nuclear-protein complex formation and disassembly. Also included are fast, local movements of chromosomes, together with slower but long-range movements of chromosomes and nuclear bodies.

Original languageEnglish (US)
Pages (from-to)304-310
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume15
Issue number3
DOIs
StatePublished - Jun 2003

ASJC Scopus subject areas

  • Cell Biology

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