Dynamics and efficiency of hole transport in LNA:DNA hybrid diblock oligomers

Arun K. Thazhathveetil; Josh Vura-Weis; Anton Trifonov; Michael R. Wasielewski; Frederick D. Lewis

doi:10.1021/ja307989t

Dynamics and efficiency of hole transport in LNA:DNA hybrid diblock oligomers

Arun K. Thazhathveetil, Josh Vura-Weis, Anton Trifonov, Michael R. Wasielewski, Frederick D. Lewis

Research output: Contribution to journal › Article › peer-review

Abstract

We report here the effect of replacing one or both of the purine or pyrimidine blocks of a diblock stilbene donor-acceptor capped hairpin with locked nucleic acid (LNA) bases on the dynamics and efficiency of hole transport. The structures of the DNA and LNA:DNA hybrids are tentatively assigned to B- or A-type structures on the basis of their circular dichroism spectra. Replacing the bases in either the A-block or the G-block of the diblock DNA hairpin with LNA bases results in a modest decrease in the base-to-base hopping rate constant and quantum yield for charge separation. Somewhat larger decreases are observed when all of the purine or pyrimidine bases are replaced by LNA bases.

Original language	English (US)
Pages (from-to)	16434-16440
Number of pages	7
Journal	Journal of the American Chemical Society
Volume	134
Issue number	39
DOIs	https://doi.org/10.1021/ja307989t
State	Published - Oct 3 2012
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

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10.1021/ja307989t

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abstract = "We report here the effect of replacing one or both of the purine or pyrimidine blocks of a diblock stilbene donor-acceptor capped hairpin with locked nucleic acid (LNA) bases on the dynamics and efficiency of hole transport. The structures of the DNA and LNA:DNA hybrids are tentatively assigned to B- or A-type structures on the basis of their circular dichroism spectra. Replacing the bases in either the A-block or the G-block of the diblock DNA hairpin with LNA bases results in a modest decrease in the base-to-base hopping rate constant and quantum yield for charge separation. Somewhat larger decreases are observed when all of the purine or pyrimidine bases are replaced by LNA bases.",

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AU - Thazhathveetil, Arun K.

AU - Vura-Weis, Josh

AU - Trifonov, Anton

AU - Wasielewski, Michael R.

AU - Lewis, Frederick D.

PY - 2012/10/3

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N2 - We report here the effect of replacing one or both of the purine or pyrimidine blocks of a diblock stilbene donor-acceptor capped hairpin with locked nucleic acid (LNA) bases on the dynamics and efficiency of hole transport. The structures of the DNA and LNA:DNA hybrids are tentatively assigned to B- or A-type structures on the basis of their circular dichroism spectra. Replacing the bases in either the A-block or the G-block of the diblock DNA hairpin with LNA bases results in a modest decrease in the base-to-base hopping rate constant and quantum yield for charge separation. Somewhat larger decreases are observed when all of the purine or pyrimidine bases are replaced by LNA bases.

AB - We report here the effect of replacing one or both of the purine or pyrimidine blocks of a diblock stilbene donor-acceptor capped hairpin with locked nucleic acid (LNA) bases on the dynamics and efficiency of hole transport. The structures of the DNA and LNA:DNA hybrids are tentatively assigned to B- or A-type structures on the basis of their circular dichroism spectra. Replacing the bases in either the A-block or the G-block of the diblock DNA hairpin with LNA bases results in a modest decrease in the base-to-base hopping rate constant and quantum yield for charge separation. Somewhat larger decreases are observed when all of the purine or pyrimidine bases are replaced by LNA bases.

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Dynamics and efficiency of hole transport in LNA:DNA hybrid diblock oligomers

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