Dynamic method of optical coherence elastography in determining viscoelasticity of polymers and tissues

Yue Wang, Nathan D. Shemonski, Steven G. Adie, Stephen A. Boppart, Michael F. Insana

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we report on a novel quantitative elastography technique that combines optical coherence tomography (OCT) with acoustic radiation force (ARF) excitation to estimate the complex modulus. Sinusoidally modulated ARF excitations between 200 - 4000 Hz generate a surface wave at the tissue surface that can be related to bulk viscoelastic (VE) properties in a manner that is both precise and quantitative. This method is very well suited to studying media at high spatial resolution and over a very broad range of force frequencies. Mechanical characterization was calibrated using hydropolymers before studying liver samples. Fresh porcine liver samples were measured over time with and without formalin fixation. These data were used to evaluate the utility of the Kelvin-Voigt rheological model commonly used to fit dispersion data when estimating modulus values. We also investigated use of square-wave force excitation to measure the step response of tissues.

Original languageEnglish (US)
Title of host publication2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages117-120
Number of pages4
DOIs
StatePublished - Oct 31 2013
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
Duration: Jul 3 2013Jul 7 2013

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
CountryJapan
CityOsaka
Period7/3/137/7/13

Fingerprint

Elasticity Imaging Techniques
Viscoelasticity
Acoustics
Liver
Polymers
Radiation
Tissue
Step response
Optical tomography
Optical Coherence Tomography
Formaldehyde
Surface waves
Swine

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Wang, Y., Shemonski, N. D., Adie, S. G., Boppart, S. A., & Insana, M. F. (2013). Dynamic method of optical coherence elastography in determining viscoelasticity of polymers and tissues. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 (pp. 117-120). [6609451] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6609451

Dynamic method of optical coherence elastography in determining viscoelasticity of polymers and tissues. / Wang, Yue; Shemonski, Nathan D.; Adie, Steven G.; Boppart, Stephen A.; Insana, Michael F.

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 117-120 6609451 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wang, Y, Shemonski, ND, Adie, SG, Boppart, SA & Insana, MF 2013, Dynamic method of optical coherence elastography in determining viscoelasticity of polymers and tissues. in 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013., 6609451, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 117-120, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 7/3/13. https://doi.org/10.1109/EMBC.2013.6609451
Wang Y, Shemonski ND, Adie SG, Boppart SA, Insana MF. Dynamic method of optical coherence elastography in determining viscoelasticity of polymers and tissues. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 117-120. 6609451. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6609451
Wang, Yue ; Shemonski, Nathan D. ; Adie, Steven G. ; Boppart, Stephen A. ; Insana, Michael F. / Dynamic method of optical coherence elastography in determining viscoelasticity of polymers and tissues. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. pp. 117-120 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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