Dual targeting of the warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor

Emilia C. Calvaresi, Carlotta Granchi, Tiziano Tuccinardi, Valeria Di Bussolo, Robert W. Huigens, Hyang Yeon Lee, Rahul Palchaudhuri, Marco Macchia, Adriano Martinelli, Filippo Minutolo, Paul J. Hergenrother

Research output: Contribution to journalArticle

Abstract

Effective glucose diet: We report the development and activity of glucose-conjugated LDH-A inhibitors designed for dual targeting of the Warburg effect (elevated glucose uptake and glycolysis) in cancer cells. Glycoconjugation could be applied to inhibitors of many enzymes involved in glycolysis or tumor metabolism.

Original languageEnglish (US)
Pages (from-to)2263-2267
Number of pages5
JournalChemBioChem
Volume14
Issue number17
DOIs
StatePublished - Nov 25 2013

Fingerprint

L-Lactate Dehydrogenase
Glycolysis
Glucose
Enzyme Inhibitors
Nutrition
Metabolism
Tumors
Neoplasms
Cells
Diet
Enzymes

Keywords

  • Warburg effect
  • cancer
  • drug design
  • glycoconjugation
  • targeted anticancer agents

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

Cite this

Calvaresi, E. C., Granchi, C., Tuccinardi, T., Di Bussolo, V., Huigens, R. W., Lee, H. Y., ... Hergenrother, P. J. (2013). Dual targeting of the warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. ChemBioChem, 14(17), 2263-2267. https://doi.org/10.1002/cbic.201300562

Dual targeting of the warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. / Calvaresi, Emilia C.; Granchi, Carlotta; Tuccinardi, Tiziano; Di Bussolo, Valeria; Huigens, Robert W.; Lee, Hyang Yeon; Palchaudhuri, Rahul; Macchia, Marco; Martinelli, Adriano; Minutolo, Filippo; Hergenrother, Paul J.

In: ChemBioChem, Vol. 14, No. 17, 25.11.2013, p. 2263-2267.

Research output: Contribution to journalArticle

Calvaresi, EC, Granchi, C, Tuccinardi, T, Di Bussolo, V, Huigens, RW, Lee, HY, Palchaudhuri, R, Macchia, M, Martinelli, A, Minutolo, F & Hergenrother, PJ 2013, 'Dual targeting of the warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor', ChemBioChem, vol. 14, no. 17, pp. 2263-2267. https://doi.org/10.1002/cbic.201300562
Calvaresi EC, Granchi C, Tuccinardi T, Di Bussolo V, Huigens RW, Lee HY et al. Dual targeting of the warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. ChemBioChem. 2013 Nov 25;14(17):2263-2267. https://doi.org/10.1002/cbic.201300562
Calvaresi, Emilia C. ; Granchi, Carlotta ; Tuccinardi, Tiziano ; Di Bussolo, Valeria ; Huigens, Robert W. ; Lee, Hyang Yeon ; Palchaudhuri, Rahul ; Macchia, Marco ; Martinelli, Adriano ; Minutolo, Filippo ; Hergenrother, Paul J. / Dual targeting of the warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. In: ChemBioChem. 2013 ; Vol. 14, No. 17. pp. 2263-2267.
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