Dual Stimuli-Responsive Poly(β-amino ester) Nanoparticles for On-Demand Burst Release

Jung Seok Lee, Xiaojian Deng, Patrick Han, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review


We designed poly(β-amino esters) (PBAEs) bearing both UV light- and pH-sensitive groups and used PBAEs to prepare nanoparticles (NPs) that can be utilized for on-demand burst release of guest molecules in response to multiple triggers. Due to the presence of the photo-cleavable group in each repeating unit of PBAE, rapid release of encapsulated model drug could be achieved even with exposures to low intensity UV (10mW·cm-2). Especially, the burst release was further accelerated by additional UV treatments in the acidic condition showing the combinatory effect of dual stimuli. We believe these PBAE-based NPs can potentially be used to design intelligent controlled release device and nanomedicines.

Original languageEnglish (US)
Pages (from-to)1314-1322
Number of pages9
JournalMacromolecular Bioscience
Issue number9
StatePublished - Sep 1 2015


  • UV-sensitive
  • nanomedicine
  • on-demand release
  • pH-sensitive
  • poly(β-amino ester)

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry


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