Abstract
We designed poly(β-amino esters) (PBAEs) bearing both UV light- and pH-sensitive groups and used PBAEs to prepare nanoparticles (NPs) that can be utilized for on-demand burst release of guest molecules in response to multiple triggers. Due to the presence of the photo-cleavable group in each repeating unit of PBAE, rapid release of encapsulated model drug could be achieved even with exposures to low intensity UV (10mW·cm-2). Especially, the burst release was further accelerated by additional UV treatments in the acidic condition showing the combinatory effect of dual stimuli. We believe these PBAE-based NPs can potentially be used to design intelligent controlled release device and nanomedicines.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1314-1322 |
| Number of pages | 9 |
| Journal | Macromolecular Bioscience |
| Volume | 15 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2015 |
Keywords
- UV-sensitive
- nanomedicine
- on-demand release
- pH-sensitive
- poly(β-amino ester)
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomaterials
- Polymers and Plastics
- Materials Chemistry