Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

Fu Yang Lin, Yonghui Zhang, Mary Hensler, Yi Liang Liu, Ohn A. Chow, Wei Zhu, Ke Wang, Ran Pang, Wdee Thienphrapa, Victor Nizet, Eric Oldfield

Research output: Contribution to journalArticlepeer-review

Original languageEnglish (US)
Pages (from-to)561-564
Number of pages4
JournalChemMedChem
Volume7
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Immunology
  • Isoprenoid biosynthesis
  • Neutrophil extracellular traps
  • Virulence factor
  • X-ray diffraction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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