Droplet-assisted phase separation by integrated silicon electrospray nano-emitter for neurochemical sensing

Yan Zhang, Weihua Shi, Insu Park, Sungho Kim, Christopher Brenden, Hrishikesh Iyer, Prasoon Jha, Rashid Bashir, Yurii Vlasov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrated a nano-electrospray ionization (n-ESI) emitter monolithically integrated on silicon chip. Chip contains an integrated T-junction droplet generator that enables segmentation of analytes flow in μm-scale microfluidic channels into a series of oil-isolated pL-volume aqueous droplets. Chip-integrated n-ESI emitter is designed to efficiently deliver segmented analytes for subsequent mass spectrometry (MS) analysis. Engineered emitter nozzle geometry enables spatial and temporal separation of electro-sprayed oil and aqueous phases to monitor sampled neurochemicals on a droplet-by-droplet basis thus promising improved temporal and chemical sensitivity.

Original languageEnglish (US)
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages110-111
Number of pages2
ISBN (Electronic)9781733419017
StatePublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: Oct 4 2020Oct 9 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period10/4/2010/9/20

Keywords

  • Droplet microfluidics
  • Electrospray ionization
  • Mass spectrometry
  • Neurochemicals

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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