TY - GEN
T1 - Droplet-assisted phase separation by integrated silicon electrospray nano-emitter for neurochemical sensing
AU - Zhang, Yan
AU - Shi, Weihua
AU - Park, Insu
AU - Kim, Sungho
AU - Brenden, Christopher
AU - Iyer, Hrishikesh
AU - Jha, Prasoon
AU - Bashir, Rashid
AU - Vlasov, Yurii
N1 - Funding Information:
ACKNOWLEDGEMENTS This work was supported by NIH grant 1UF1 NS107677-01. REFERENCES [1] T.Ngernsutivorakul, et al., Anal. Chem. 90, 10943, 2018. [2] G.Petit-Pierre, et al., Nat. Commun. 8, 1239, 2017
Publisher Copyright:
© 2020 CBMS-0001
PY - 2020
Y1 - 2020
N2 - We demonstrated a nano-electrospray ionization (n-ESI) emitter monolithically integrated on silicon chip. Chip contains an integrated T-junction droplet generator that enables segmentation of analytes flow in μm-scale microfluidic channels into a series of oil-isolated pL-volume aqueous droplets. Chip-integrated n-ESI emitter is designed to efficiently deliver segmented analytes for subsequent mass spectrometry (MS) analysis. Engineered emitter nozzle geometry enables spatial and temporal separation of electro-sprayed oil and aqueous phases to monitor sampled neurochemicals on a droplet-by-droplet basis thus promising improved temporal and chemical sensitivity.
AB - We demonstrated a nano-electrospray ionization (n-ESI) emitter monolithically integrated on silicon chip. Chip contains an integrated T-junction droplet generator that enables segmentation of analytes flow in μm-scale microfluidic channels into a series of oil-isolated pL-volume aqueous droplets. Chip-integrated n-ESI emitter is designed to efficiently deliver segmented analytes for subsequent mass spectrometry (MS) analysis. Engineered emitter nozzle geometry enables spatial and temporal separation of electro-sprayed oil and aqueous phases to monitor sampled neurochemicals on a droplet-by-droplet basis thus promising improved temporal and chemical sensitivity.
KW - Droplet microfluidics
KW - Electrospray ionization
KW - Mass spectrometry
KW - Neurochemicals
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M3 - Conference contribution
AN - SCOPUS:85098237941
T3 - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 110
EP - 111
BT - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
Y2 - 4 October 2020 through 9 October 2020
ER -