Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform

Yan Zhang, Sungho Kim, Weihua Shi, Yaoyao Zhao, Insu Park, Christopher Brenden, Hrishikesh Iyer, Prasoon Jha, Rashid Bashir, Jonathan V. Sweedler, Yurii Vlasov

Research output: Contribution to journalArticlepeer-review

Abstract

We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and aqueous phases during electro-spray for subsequent mass spectrometry analysis.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalLab on a chip
Volume22
Issue number1
DOIs
StatePublished - Jan 7 2022

ASJC Scopus subject areas

  • General Chemistry
  • Bioengineering
  • Biochemistry
  • Biomedical Engineering

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