Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform

Yan Zhang; Sungho Kim; Weihua Shi; Yaoyao Zhao; Insu Park; Christopher Brenden; Hrishikesh Iyer; Prasoon Jha; Rashid Bashir; Jonathan V. Sweedler; Yurii Vlasov

doi:10.1039/d1lc00758k

Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform

Yan Zhang, Sungho Kim, Weihua Shi, Yaoyao Zhao, Insu Park, Christopher Brenden, Hrishikesh Iyer, Prasoon Jha, Rashid Bashir, Jonathan V. Sweedler, Yurii Vlasov

Research output: Contribution to journal › Article › peer-review

Abstract

We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and aqueous phases during electro-spray for subsequent mass spectrometry analysis.

Original language	English (US)
Pages (from-to)	40-46
Number of pages	7
Journal	Lab on a chip
Volume	22
Issue number	1
DOIs	https://doi.org/10.1039/d1lc00758k
State	Published - Jan 7 2022

ASJC Scopus subject areas

General Chemistry
Bioengineering
Biochemistry
Biomedical Engineering

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10.1039/d1lc00758k

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AU - Zhang, Yan

AU - Kim, Sungho

AU - Shi, Weihua

AU - Zhao, Yaoyao

AU - Park, Insu

AU - Brenden, Christopher

AU - Iyer, Hrishikesh

AU - Jha, Prasoon

AU - Bashir, Rashid

AU - Sweedler, Jonathan V.

AU - Vlasov, Yurii

PY - 2022/1/7

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AB - We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and aqueous phases during electro-spray for subsequent mass spectrometry analysis.

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Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform

Abstract

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