Drive the car(go)s—new modalities to control cargo trafficking in live cells

Payel Mondal, John S. Khamo, Vishnu V. Krishnamurthy, Qi Cai, Kai Zhang

Research output: Contribution to journalReview article

Abstract

Synaptic transmission is a fundamental molecular process underlying learning and memory. Successful synaptic transmission involves coupled interaction between electrical signals (action potentials) and chemical signals (neurotransmitters). Defective synaptic transmission has been reported in a variety of neurological disorders such as Autism and Alzheimer’s disease. A large variety of macromolecules and organelles are enriched near functional synapses. Although a portion of macromolecules can be produced locally at the synapse, a large number of synaptic components especially the membrane-bound receptors and peptide neurotransmitters require active transport machinery to reach their sites of action. This spatial relocation is mediated by energy-consuming, motor protein-driven cargo trafficking. Properly regulated cargo trafficking is of fundamental importance to neuronal functions, including synaptic transmission. In this review, we discuss the molecular machinery of cargo trafficking with emphasis on new experimental strategies that enable direct modulation of cargo trafficking in live cells. These strategies promise to provide insights into a quantitative understanding of cargo trafficking, which could lead to new intervention strategies for the treatment of neurological diseases.

Original languageEnglish (US)
Article number4
JournalFrontiers in Molecular Neuroscience
Volume10
DOIs
StatePublished - Jan 20 2017

Fingerprint

Synaptic Transmission
Synapses
Neurotransmitter Receptor
Peptide Receptors
Active Biological Transport
Autistic Disorder
Nervous System Diseases
Organelles
Action Potentials
Neurotransmitter Agents
Alzheimer Disease
Learning
Membranes
Drive
Proteins

Keywords

  • Axonal transport
  • Cargo trafficking
  • Chemically induced dimerization
  • Motor proteins
  • Neurological disorders
  • Optogenetics
  • Photoactivatable proteins
  • Synaptic transmission

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Drive the car(go)s—new modalities to control cargo trafficking in live cells. / Mondal, Payel; Khamo, John S.; Krishnamurthy, Vishnu V.; Cai, Qi; Zhang, Kai.

In: Frontiers in Molecular Neuroscience, Vol. 10, 4, 20.01.2017.

Research output: Contribution to journalReview article

Mondal, Payel ; Khamo, John S. ; Krishnamurthy, Vishnu V. ; Cai, Qi ; Zhang, Kai. / Drive the car(go)s—new modalities to control cargo trafficking in live cells. In: Frontiers in Molecular Neuroscience. 2017 ; Vol. 10.
@article{6bf7b6ee191c4b0cb5ea34738f05eee6,
title = "Drive the car(go)s—new modalities to control cargo trafficking in live cells",
abstract = "Synaptic transmission is a fundamental molecular process underlying learning and memory. Successful synaptic transmission involves coupled interaction between electrical signals (action potentials) and chemical signals (neurotransmitters). Defective synaptic transmission has been reported in a variety of neurological disorders such as Autism and Alzheimer’s disease. A large variety of macromolecules and organelles are enriched near functional synapses. Although a portion of macromolecules can be produced locally at the synapse, a large number of synaptic components especially the membrane-bound receptors and peptide neurotransmitters require active transport machinery to reach their sites of action. This spatial relocation is mediated by energy-consuming, motor protein-driven cargo trafficking. Properly regulated cargo trafficking is of fundamental importance to neuronal functions, including synaptic transmission. In this review, we discuss the molecular machinery of cargo trafficking with emphasis on new experimental strategies that enable direct modulation of cargo trafficking in live cells. These strategies promise to provide insights into a quantitative understanding of cargo trafficking, which could lead to new intervention strategies for the treatment of neurological diseases.",
keywords = "Axonal transport, Cargo trafficking, Chemically induced dimerization, Motor proteins, Neurological disorders, Optogenetics, Photoactivatable proteins, Synaptic transmission",
author = "Payel Mondal and Khamo, {John S.} and Krishnamurthy, {Vishnu V.} and Qi Cai and Kai Zhang",
year = "2017",
month = "1",
day = "20",
doi = "10.3389/fnmol.2017.00004",
language = "English (US)",
volume = "10",
journal = "Frontiers in Molecular Neuroscience",
issn = "1662-5099",
publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Drive the car(go)s—new modalities to control cargo trafficking in live cells

AU - Mondal, Payel

AU - Khamo, John S.

AU - Krishnamurthy, Vishnu V.

AU - Cai, Qi

AU - Zhang, Kai

PY - 2017/1/20

Y1 - 2017/1/20

N2 - Synaptic transmission is a fundamental molecular process underlying learning and memory. Successful synaptic transmission involves coupled interaction between electrical signals (action potentials) and chemical signals (neurotransmitters). Defective synaptic transmission has been reported in a variety of neurological disorders such as Autism and Alzheimer’s disease. A large variety of macromolecules and organelles are enriched near functional synapses. Although a portion of macromolecules can be produced locally at the synapse, a large number of synaptic components especially the membrane-bound receptors and peptide neurotransmitters require active transport machinery to reach their sites of action. This spatial relocation is mediated by energy-consuming, motor protein-driven cargo trafficking. Properly regulated cargo trafficking is of fundamental importance to neuronal functions, including synaptic transmission. In this review, we discuss the molecular machinery of cargo trafficking with emphasis on new experimental strategies that enable direct modulation of cargo trafficking in live cells. These strategies promise to provide insights into a quantitative understanding of cargo trafficking, which could lead to new intervention strategies for the treatment of neurological diseases.

AB - Synaptic transmission is a fundamental molecular process underlying learning and memory. Successful synaptic transmission involves coupled interaction between electrical signals (action potentials) and chemical signals (neurotransmitters). Defective synaptic transmission has been reported in a variety of neurological disorders such as Autism and Alzheimer’s disease. A large variety of macromolecules and organelles are enriched near functional synapses. Although a portion of macromolecules can be produced locally at the synapse, a large number of synaptic components especially the membrane-bound receptors and peptide neurotransmitters require active transport machinery to reach their sites of action. This spatial relocation is mediated by energy-consuming, motor protein-driven cargo trafficking. Properly regulated cargo trafficking is of fundamental importance to neuronal functions, including synaptic transmission. In this review, we discuss the molecular machinery of cargo trafficking with emphasis on new experimental strategies that enable direct modulation of cargo trafficking in live cells. These strategies promise to provide insights into a quantitative understanding of cargo trafficking, which could lead to new intervention strategies for the treatment of neurological diseases.

KW - Axonal transport

KW - Cargo trafficking

KW - Chemically induced dimerization

KW - Motor proteins

KW - Neurological disorders

KW - Optogenetics

KW - Photoactivatable proteins

KW - Synaptic transmission

UR - http://www.scopus.com/inward/record.url?scp=85010977515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010977515&partnerID=8YFLogxK

U2 - 10.3389/fnmol.2017.00004

DO - 10.3389/fnmol.2017.00004

M3 - Review article

AN - SCOPUS:85010977515

VL - 10

JO - Frontiers in Molecular Neuroscience

JF - Frontiers in Molecular Neuroscience

SN - 1662-5099

M1 - 4

ER -