Downhill protein folding: Evolution meets physics

Research output: Contribution to journalShort surveypeer-review


Proteins can be redesigned to fold downhill on a free energy surface characterized by only a few coordinates, confirming a principal prediction of the 'energy-landscape' model. Nonetheless, natural proteins have small but significant barriers. Spectroscopy and kinetics reveal potential biological causes for activation barriers during protein folding: evolution against protein aggregation and for protein function.

Original languageEnglish (US)
Pages (from-to)701-712
Number of pages12
JournalComptes Rendus - Biologies
Issue number8
StatePublished - Aug 2005


  • Activation barrier
  • Hydrophobicity
  • Protein function
  • Temperature jump

ASJC Scopus subject areas

  • General Medicine


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