Dose-dependent effect of ultrasound on fetal weight in mice

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Outbred non-Swiss albino mice (CF1) were time-mated, exposed on the eighth day of gestation to 1 MHz continuous wave ultrasound, and examined on the eighteenth day of gestation. Seven exposure conditions (spatial average intensity versus exposure time) were employed for the 272 litters: 0 W/cm2 (sham); 0.5 W/cm2, 300 sec; 0.7 W/cm2, 300 sec; 2.0 W/cm2, 20 sec; 3.0 W/cm2, 20 sec; 3.0 W/cm2, 10 sec; and 5.5 W/cm2, 10 sec. Relative to the sham group, every exposed group exhibited a reduced average fetal weight, ranging from 5.3 to 17.5 per cent, and the nonparametric Kruskal-Wallis one-way analysis of variance by ranks indicated that the average fetal weight varied significantly, at the 0.001 level, with exposure condition. In addition, a linear dose-effect dependence of exposure condition versus average fetal weight was observed, in which the dose parameter was defined as I2t, where I is the spatial average exposure intensity and t is the exposure time.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Ultrasound in Medicine
Issue number1
StatePublished - 1983

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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