TY - JOUR
T1 - Do hospitals that participate in COVID-19 research differ from non-trial hospitals? A cross-sectional study of US hospitals
AU - Kang, Daniel
AU - Huang, Cher X.
AU - Yuen, Alexander D.
AU - Norris, Keith C.
AU - Vijayan, Tara
N1 - Funding Information:
The authors are funded by the NSF GRFP, Google PhD scholarship, and National Institutes of Health grants P30AG021684, UL1TR001881.
Publisher Copyright:
© 2023, BioMed Central Ltd., part of Springer Nature.
PY - 2023/12
Y1 - 2023/12
N2 - Objectives: To compare hospitals that did and did not participate in clinical trials evaluating potential inpatient COVID-19 therapeutics. Methods: We conducted a cross-sectional study of hospitals participating in trials that were registered on clinicaltrials.gov between April and August 2020. Using the 2019 RAND Hospital Dataset and 2019 American Community Survey, we used logistic regression modeling to compare hospital-level traits including demographic features between trial and non-trial hospitals. Results: We included 488 hospitals that were participating in 298 interventional trials and 4232 non-participating hospitals. After controlling for demographic and other hospital traits, we found that teaching status (OR 2.11, 95% CI 1.52–2.95), higher patient acuity (OR 7.48, 4.39, 13.1), and location in the Northeast (OR 1.83, 95% CI 1.18, 2.85) and in wealthier counties (OR: 1.32, 95% CI 1.16–1.51) were associated with increased odds of trial participation, while being in counties with more White residents was associated with reduced odds (OR 0.98, 95% CI 0.98–0.99). Conclusions: Hospitals participating and not participating in COVID-19 inpatient treatment clinical trials differed in many ways, resulting in important implications for the generalizability of trial data.
AB - Objectives: To compare hospitals that did and did not participate in clinical trials evaluating potential inpatient COVID-19 therapeutics. Methods: We conducted a cross-sectional study of hospitals participating in trials that were registered on clinicaltrials.gov between April and August 2020. Using the 2019 RAND Hospital Dataset and 2019 American Community Survey, we used logistic regression modeling to compare hospital-level traits including demographic features between trial and non-trial hospitals. Results: We included 488 hospitals that were participating in 298 interventional trials and 4232 non-participating hospitals. After controlling for demographic and other hospital traits, we found that teaching status (OR 2.11, 95% CI 1.52–2.95), higher patient acuity (OR 7.48, 4.39, 13.1), and location in the Northeast (OR 1.83, 95% CI 1.18, 2.85) and in wealthier counties (OR: 1.32, 95% CI 1.16–1.51) were associated with increased odds of trial participation, while being in counties with more White residents was associated with reduced odds (OR 0.98, 95% CI 0.98–0.99). Conclusions: Hospitals participating and not participating in COVID-19 inpatient treatment clinical trials differed in many ways, resulting in important implications for the generalizability of trial data.
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U2 - 10.1186/s13063-023-07450-6
DO - 10.1186/s13063-023-07450-6
M3 - Article
C2 - 37550662
AN - SCOPUS:85166784669
SN - 1745-6215
VL - 24
JO - Trials
JF - Trials
IS - 1
M1 - 504
ER -